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The role and structure of the multidisciplinary team in the management of advanced Parkinson’s disease with a focus on the use of levodopa–carbidopa intestinal gel

Authors Pedersen SW, Suedmeyer M, Liu LWC, Domagk D, Forbes A, Bergmann L, Onuk K, Yegin A, van Laar T

Received 25 April 2016

Accepted for publication 18 August 2016

Published 4 January 2017 Volume 2017:10 Pages 13—27


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Scott Fraser

Video abstract presented by Stephen W Pedersen.

Views: 480

Stephen W Pedersen,1 Martin Suedmeyer,2 Louis W C Liu,3 Dirk Domagk,4 Alison Forbes,5 Lars Bergmann,6 Koray Onuk,6 Ashley Yegin,6 Teus van Laar7

1Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark; 2Department of Neurology, University of Düesseldorf, Düesseldorf, Germany; 3Division of Gastroenterology, Department of Medicine, University of Toronto, University Health Network, Toronto, ON, Canada; 4Department of Medicine I, Josephs-Hospital Warendorf, Academic Teaching Hospital, University of Muenster, Warendorf, Germany; 5PDNS consultant, AbbVie Inc., Roswell, GA, USA; 6Global Medical Affairs, AbbVie Inc., North Chicago, IL, USA; 7Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands

Abstract: A multidisciplinary team (MDT) approach is increasingly recommended in Parkinson’s disease (PD) treatment guidelines, but no standard of care exists for such an approach, and the guidelines do not provide clarification on how it should be implemented. This paper reviews evidence of MDT interventions in people with PD and provides expert clinical perspectives for an MDT approach, with a focus on advanced PD and levodopa–carbidopa intestinal gel (carbidopa–levodopa enteral suspension in the USA). The key recommendations are to enable the best possible treatment of people with PD locally by facilitating a close structured collaboration of different health care professionals working in a fixed network structure; to refer people with PD to established MDT centers in a timely manner; to establish regular meetings for the MDT enabling interdisciplinary exchange and learning; to optimize individual treatment and carefully evaluate available treatment options; to ensure treatment decisions are agreed jointly between people with PD, their caregivers, family, and health care professional; and to include specialists outside of neurology from adjuvant medical departments as necessary when implementing advanced therapies.

Keywords: Parkinson’s disease, multidisciplinary team, advanced therapy, levodopa–carbidopa intestinal gel, carbidopa–levodopa enteral suspension


A multidisciplinary team (MDT) approach has been shown to improve the quality of life (QoL)15 and motor function1,2,48 for people with Parkinson’s disease (PD) and QoL for their caregivers.911 Although limited studies are available, it is clear that people with PD benefit from such an approach (Table 1), and as such, it is increasingly recommended in PD treatment guidelines.12,13 Up to 20 different health care professionals may provide beneficial interventions,14 but no standard of care exists for an MDT approach, and the guidelines do not provide clarification on how it should be implemented. As a result, although the prevalence of PD increases with age to nearly 2% (1,903/100,000) in those over 80 years of age worldwide,15 many people with PD receive suboptimal management.

Table 1 Summary of studies investigating the effect of multidisciplinary interventions in people with PD

Abbreviations: ADLs, activities of daily living; ALDS, Academic Medical Center linear disability score; BBS, Berg Balance Scale; CSI, Caregiver Strain Index; DBS, Deep Brain Stimulation; EQ-5D, European Quality of Life Group – five dimensions; FIM, Functional Independence Measure; HADs, Hospital Anxiety and Depression Scale; QoL, quality of life; HRQoL, health-related quality of life; MADRS, Montgomery–Asberg Depression Scale; MDS, Movement Disorder Society; MDT, Multidisciplinary Team; MMSE, Mini–Mental State Examination; NMSS, Non-Motor Symptom Scale; PD, Parkinson’s disease; PDNS, Parkinson’s disease nurse specialist; PDQ-39, 39-item Parkinson’s Disease Questionnaire; PDSS, Parkinson’s Disease Sleep Scale; PMS, Global patient’s mood status; RCT, randomized controlled trial; SCOPA-PS, Scales for Outcomes in Parkinson’s Disease – Psychosocial; SDS, Zung Self-Rating Depression Scale; SEADL, Schwab and England Activities of Daily Living; SF-36, Short Form 36-item health survey; SPDDS, Self-Assessment Parkinson’s Disease Disability Scale; UPDRS, Unified Parkinson’s Disease Rating Scale.

The lack of a clear definition of advanced PD16 creates a further challenge. Furthermore, people who have been identified as having advanced PD are often not referred for advanced therapies,17 which can improve their motor function and QoL.18 These therapies – deep brain stimulation (DBS),19 subcutaneous apomorphine pump,20 and levodopa–carbidopa intestinal gel (LCIG; carbidopa–levodopa enteral suspension in the USA),21 – require specialized MDTs to ensure successful implementation. However, experience in establishing and working within such specialized MDTs is limited.

This paper reviews the literature and shares the extensive relevant experiences of the authors to help address gaps in clinical practice and guidelines concerning MDT management of advanced PD, timely referral of people with PD for advanced therapies, and implementation of advanced therapies (with special attention to LCIG therapy).

Literature search strategy and selection criteria

Studies were identified through a PubMed literature search using the following search terms: multidisciplinary/interdisciplinary/multispecialty AND Parkinson’s disease AND study. This yielded 90 hits – the abstracts were screened for suitability. Only studies investigating the impact of multidisciplinary care in people with PD were included. Reviews (systematic and other), nonrelevant articles, and studies in which only the protocol and study design were discussed were excluded from the results. The literature search was performed in July 2016.

Who is in the MDT?

The MDT comprises up to 20 different collaborating health care professionals centered on the person with PD and their caregiver, to provide comprehensive care to meet as many of the patient’s health and other needs as possible (Table 2).12,14,22 The involvement of a PD nurse specialist (PDNS),12,14,22,23 to offer support at the individual level, education to the wider community, and training of clinical and nonclinical staff,24 complements the interventions of the rest of the team to improve the QoL of people with PD and their caregivers.25

Table 2 Members of the MDT listed by the European Parkinson’s Disease Standards of Care Consensus Statement and their role in the care and management of people with PD12

Note: Data from The European Parkinson’s Disease Standards of Care Consensus Statement.12

Abbreviations: PD, Parkinson’s disease; MDT, multidisciplinary team; PDNS, Parkinson’s disease nurse specialist.

As PD progresses to advanced PD,26 device-aided advanced therapies become an option to improve motor function and QoL.18 At this stage, additional members of the MDT include neurosurgeons and gastroenterologists with a special interest and expertise in managing people with advanced PD indicated for DBS or LCIG, respectively.

Roles and responsibilities within the MDT

The PD MDT composition and the roles/responsibilities of each member require clear definition so that they can work both individually and collaboratively to achieve a common set of treatment objectives. The involvement of different MDT members at any one time depends on the needs of the person with PD and their caregiver, and the stage of their disease. Effective interventions preserve the caregiver’s well-being, and allow people with PD to remain at home with appropriate assistance.9

Ideally, various networks exist and interact within the MDT (Figure 1A). In Denmark, for example:

Figure 1 Examples of multidisciplinary team networks aiming to provide comprehensive and collaborative care for people with PD.

Notes: (A) Network interaction within the PD multidisciplinary team in Denmark supporting information exchange about patients. (B) The Rigshospitalet Glostrup model.

Abbreviations: PD, Parkinson’s disease; DBS, deep brain stimulation; GP, general practitioner; MDS, movement disorder specialist; PDNS, Parkinson’s disease nurse specialist.

  1. A triangular network exists for day-to-day management between general community nurses, a key community nurse trained in PD who can answer most day-to-day questions, and a hospital-based PDNS.

  2. A vertical network provides nurses in the community with access to expert advice and information from the PDNS and neurologist.

  3. Horizontal networks in the hospital facilitate treatment of advanced PD between movement disorder specialists (MDSs)/specialist neurologists, gastroenterologists, and neurosurgeons, and between nurses from different departments.

The complex, but not complicated, multidisciplinary Glostrup model (Figure 1B) depicts the interactions and networks between all members of the PD MDT with the person with PD, their caregiver, the MDS, and the PDNS at the center. A strong collaboration between hospital and community nurses is essential with this approach.

People with PD and their caregivers require clear information and education about their therapeutic options throughout the disease, including the possible advantages and disadvantages, to ensure that treatments are used appropriately to achieve the best possible QoL and motor function.17,27 The MDS and PDNS are experts in the provision of such information, and all newly diagnosed people with PD should be referred to a specialized MDT with a PDNS as soon as possible after diagnosis.17,24,27 The PDNS can then liaise with and involve the MDS and other members of the MDT as required.

The MDS and PDNS aim to provide seamless care and information and provide newly diagnosed people with PD with the opportunity to talk about and discuss the diagnosis in more detail. They can help them come to terms with the diagnosis, how it might affect them, and how they can manage it.24

Caregivers also play an important role in the team of individuals supporting people with PD. While offering assistance with activities of daily living, they are also involved with the management of PD-related tasks (appointments, medication) and treatment decisions. At all stages of the disease, treatment decisions should be made jointly between the person with PD, their caregiver, family, and health care practitioners.28 Greater involvement in treatment decisions leads to significantly greater satisfaction and distress relief in people with PD.29 Furthermore, engaging people with PD and their caregivers to understand PD and the therapies available could lead to improved adherence to therapy, as has been demonstrated in diabetes patients.30

A further role for the MDS and PDNS is to discuss advanced therapies with people with PD and their caregivers early in the disease course. To avoid “end-stage” perception, it is important they highlight that there may be a time when existing therapies are no longer effective, and at this point advanced therapies may offer much-needed improvements in QoL and motor function.21,3133 They can then discuss with the MDS how to derive maximum benefit from such treatment when it becomes the appropriate option.

Identification of people with PD for advanced therapy, and selection and implementation of the appropriate therapy

Treatment with oral dopaminergic therapies usually controls motor symptoms in early PD, but as PD progresses it becomes less effective, resulting in motor and nonmotor fluctuations and dyskinesias.34 The reasons for this are poorly understood, but probably involve pharmacokinetic factors.35 The progression of PD has a substantial impact on health-related QoL.36 During long-term follow-up, deterioration in physical mobility has been shown to be the most important factor contributing to decline in health-related QoL.37 A relationship between QoL for the person with PD and the caregiver’s perceived burden has also been demonstrated.38 At this stage of PD, it is important to ensure timely referral to an MDS before complications develop and QoL deteriorates.17

Advanced therapies may be appropriate when motor fluctuations become refractory to adjustments in oral and transdermal medications and when such adjustments are complicated by the emergence (or worsening) of dyskinesias.39,40 Simplified criteria to help improve recognition of the advanced stages of PD despite an optimized oral drug regimen can include:

  1. unpredictable fluctuations;

  2. more than 2 hours “off”-time/d;

  3. over five doses of medication/d;

  4. impaired activities of daily living.18

Raising awareness about when a person with PD might benefit from an advanced therapy is a key responsibility for the MDS. The PDNS, in providing individual care to alleviate the impact of PD on daily life, is well placed to assess whether a patient might derive more autonomy with an advanced therapy.41

Once the MDS has identified that a person with PD might benefit from an advanced therapy, he or she can discuss the options, advantages, and disadvantages of each treatment, and advise on how the advanced therapy can improve the patient’s symptoms. The PDNS can help the patient and their caregiver take an active role in the decision-making process,24,41 for example, by providing a portable test pump and tubing so that the person with PD can experience how it might feel to wear and carry it every day.

The PDNS and MDS aim to align the expectations of the person with PD and their caregiver with what can be achieved from a particular type of advanced therapy.

The regional MDT approach in the Netherlands (ParkinsonNet) improves quality of care and reduces health care costs

In the Netherlands, regional MDTs specialize in providing a particular type of advanced PD therapy.42 Such regional cooperation has improved the quality of care and reduced health care costs for people with PD.43

All teams meet together regularly to discuss those people with PD who might have an indication for advanced therapy in their area and to exchange experience and knowledge. These meetings involve 10–15 MDSs and 10–15 PDNSs from the university hospital and the larger regional hospitals in the area. Decisions are made on the most suitable advanced therapy for each individual with PD using a matrix (Table 3) that takes into account medical conditions, for example, impaired cognitive function. Recently published expert opinion recommendations give some guidance on the management of people with mild or moderate cognitive impairment.18

Table 3 Matrix used in the Netherlands to help decide upon the most suitable advanced therapy for each individual with PD

Notes: +, factor strengthens the decision to select the device-aided therapy; 0, factor does not influence the decision; –, factor argues against selecting the device-aided therapy.

Abbreviations: PD, Parkinson’s disease; LCIG, levodopa–carbidopa intestinal gel; DBS, deep brain stimulation; ICD, impulse control disorder.

ParkinsonNet (Nijmegen, the Netherlands) is also largely focused on “participatory medicine”, encouraging people with PD to take an active role in the management of their disease and act as partners in the decision-making process.28 They are then referred to a center, providing the chosen therapy, close to their home. To enable this collaboration, patients need to be well-informed and empowered to make a choice, through the provision of unbiased medical information presented in a way that can be easily understood.28 This collaboration requires physicians to “guide” patients, rather than telling them what to do.28 A decision aid to support people with PD make a choice about advanced therapies is being developed and was recently trialed with 19 patients.44 Overall, 100% of the participants stated that they would use the aid if faced with the choice, with 88% saying that the information was well balanced. The aid is currently being modified to include more first-hand patient experiences, and to include more practical information.44

ParkinsonNet has not only provided more joined-up care for people with PD centered around evidence-based recommendations and best practice guidelines, but also reduced health care costs by approximately €20 million each year, illustrating that informed patients make the right decisions.45

The Düsseldorf Parkinson MDT network approach in Germany improves MDT communication and increases the individual with PD’s confidence in innovative therapies

The Düsseldorf Parkinson network is another approach to the MDT management of PD.46 A university-hospital–based MDS together with a PDNS and a general neurologist jointly see and discuss patients attending the general neurologist’s outpatient clinic. A diagnostic and therapeutic treatment strategy, such as planning an advanced therapy, can usually be developed at the time. This leads to greatly improved interaction and communication between experts from the Movement Disorders Center and the general neurologist; and involvement of the general neurologist increases the individual with PD’s confidence in innovative therapeutic options. Treatment can then be initiated promptly to improve the individual’s QoL.

After the joint outpatient consultation, the diagnostic and therapeutic procedures are carefully planned in close consultation with the cooperating specialized disciplines (eg, gastroenterology for LCIG, neurosurgery for DBS) before the patient’s admission to ensure optimal resource utilization and effective clinical treatment.

The network has recently incorporated an integrated care contract, which includes the following approaches:

  1. If the patient agrees to a proposed hospital admission, for example, to carry out LCIG therapy or DBS, then the patient’s data are forwarded to the patient manager of the university hospital. The patient manager immediately arranges the inpatient stay, the relevant interdisciplinary consultation with other specialized disciplines (eg, gastroenterology, neurosurgery), and the admission appointment with the patient by telephone.

  2. After the procedure, the patient is usually seen again at a joint consultation with their general neurologist, the MDS, and the PDNS to discuss and manage the new treatment. The PDNS may visit the patient at home up to four times during a 12-month period to offer further education or assistance in the handling of an invasive PD therapy.

  3. The patient may receive a telemedicine care program,47 in which case patient-related data are passed to the authorized PDNS, who then schedules a 4-week treatment period after consulting the insurance provider and the patient.

Implementing LCIG therapy

LCIG is an effective treatment option for advanced PD that significantly improves patients QoL and motor fluctuations. It is approved for the treatment of advanced levodopa-responsive PD with severe motor fluctuations and hyperkinesia/dyskinesia when available combinations of Parkinson medicinal products have not given satisfactory results.48 For long-term administration, LCIG is administered with a portable pump directly into the jejunum by a percutaneous endoscopic gastrostomy49 with a jejunal extension tube (PEG-J).48,50 This alleviates the pharmacokinetic issues associated with oral levodopa–carbidopa, bypassing the often erratic gastric emptying in advanced PD.35 The PEG-J procedure requires close cooperation between the MDS, a gastroenterologist skilled in carrying out the procedure in patients with PD, and nurses in the neurology and gastroenterology departments.

Accessibility to the gastroenterologist, whose expertise is required before, during, and after the procedure, and to deal with any problems or questions that might arise, is key. Some gastroenterologists may not be familiar with the PEG-J tubing and connections required for LCIG therapy, and so time will be required for:

  1. familiarization with the equipment and

  2. to develop understanding of the dyskinesias that occur in PD to ensure they do not interfere with the procedure.

It is important to optimize PD medication before PEG-J placement in order to achieve a balance between patient rigidity and dyskinesia, and facilitate insertion.51,52

The PDNS ensures coordination between the person with PD, the caregiver, and all members of the MDT before, during, and after the procedure. It is useful to have an established protocol. In one center in Madrid, Spain (Hospital General Universidad Gregorio Marañón ), a one-page wall-mounted illustrated protocol clarifies nursing roles and responsibilities throughout the titration process (Figure 2).

Figure 2 The one-page, wall-mounted illustrated titration protocol clarifying the role and responsibilities of nurses throughout the titration process at the Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Notes: This poster is one component of the hospital’s “clinical pathway” that coordinates the protocols for each role in the MDT. Steps of this protocol reflect regional use and not necessarily label instructions for this product. Courtesy from Drs Carmen Funes Molina and Francisco Grandas, (translated from Spanish).

Abbreviations: IV, intravenous; PEG, percutaneous endoscopic gastrostomy; ECG, electrocardiography; LCIG, levodopa-carbidopa intestinal gel.

In Denmark, the nurses in the neurology department take much of the postprocedural responsibility and are trained to manage the PEG-J, though can seek assistance from nurses in the gastroenterology department. The person with PD and their caregiver are trained to handle the pump and the practicalities of the treatment. They are also provided with contact numbers for specially trained community nurses and the hospital-based PDNS, along with advice about who to call and when.

At German model institutions, experience has shown that it is essential that the collaborating gastroenterologist is a skilled interventional endoscopist who is familiar with the procedure, the pitfalls, and the potential complications. Before starting the 2-day test phase with a nasointestinal tube, PD patients are routinely examined using fiberendoscopic evaluation of swallowing, videofluoroscopy, functional transnasal endoscopy to investigate the esophageal phase of deglutition,53 high-resolution manometry, and endoscopy to assess the feasibility of the PEG-J procedure. However, most PEG-J placements worldwide are performed without this extensive workup.

Following standard operating procedures, and after a single dose of antibiotic intravenously, at least a transabdominal ultrasound should be performed to exclude anatomic problems, after which both nasointestinal tubes and PEG-J are placed on an inpatient basis. After successful implementation of the treatment, the patients are followed up in hospital, and at discharge, they are provided with domestic nursing staff to provide professional assistance.

A Canadian outpatient model significantly reduces the burden on limited health care resources

In Canada, an outpatient ambulatory model significantly reduces the cost for initiating LCIG and the burden on limited health care resources. It also offers greater flexibility in scheduling because it does not depend on the availability of an inpatient bed.54

In this model, a gastroenterologist is an integral part of the MDT and carries out a preprocedure consultation to screen for contraindications, to provide information on the insertion process and the risks and complications, and to obtain consent. The LCIG nurse (a hospital PD nurse trained in the LCIG pump system and titration) provides further information on the PEG-J and aftercare.

The PEG-J procedure is carried out on the outpatient endoscopy unit. The patient is under conscious sedation or given propofol for deep sedation, depending on clinician’s judgment and the level of dyskinesia. This involves close collaboration between the gastroenterologist, anesthesiologist, and movement disorder team. Appropriate placement of the J-tube is confirmed using a portable abdominal X-ray with contrast injected into the J-tube. The patient is discharged from the unit on recovery from the sedation. The next day, the gastroenterologist examines the stoma and confirms correct placement of the PEG-J in the ambulatory clinic.

Once the fistula tract of the PEG-J has matured, the patient returns for outpatient medication titration over a few days. The LCIG nurses titrate the LCIG dosage under the supervision of the neurologist and take a lead role in managing the pump; they are trained in basic stoma care and supported by the gastroenterologist.

The patients are followed up every 3 or 6 months, and the gastroenterologist examines the stoma and PEG-J placement at each visit.

It has proved beneficial for the trained gastroenterologist to train gastroenterologists in other centers and share best practices and learnings.

One consideration of this outpatient model is that patients who live at some distance from the health care center may find it difficult to attend the ambulatory clinic the following day and during the initial LCIG titrating phase. This can be overcome by providing accommodation in nearby housing or a hostel.


The multifaceted nature of PD naturally lends itself to a multidisciplinary approach to care.55 A well-structured MDT can provide essential support in many areas of disease management, for example, with therapy decisions, which can become more complex as the disease progresses. Raising awareness about when a person with PD might benefit from an advanced therapy is a key responsibility for both the MDS and PDNS. The PDNS and MDS aim to align the expectations of the person with PD and their caregiver with what can be achieved from a particular type of advanced therapy. Through “participatory medicine” it is crucial that the MDT, while empowering people with PD and their caregivers to take an active role in management of their disease, provide unbiased information and advice as and when appropriate, tailoring it to the individual.28

Available studies show that people with PD and their caregivers benefit from joined-up multidisciplinary care, although the number of reports in this area is still limited and very few controlled studies are available.18,10,11,5658 The key to the optimal management of people with PD at all stages of the disease, and successful implementation of advanced therapies, is an effective MDT approach, such as those models described in this paper. An optimal MDT structure can provide benefits for the patient and his or her caregiver, in addition to optimizing the success of treatment. With the increasing prevalence and burden of PD, and rising health care costs, the financial implications of such models are ever more important. In the Netherlands, regional MDTs that specialize in providing a particular type of advanced PD therapy (ParkinsonNet)42 have not only improved the quality of care but also decreased health care costs.43 In Germany, the Düsseldorf Parkinson network has led to greatly improved interaction and communication between experts from the Movement Disorders Center and the general neurologist, enabling more efficient initiation of advanced therapies. In Canada, the outpatient ambulatory model has been established for LCIG onboarding, to overcome the challenge and cost of obtaining inpatient beds.

Intensive multidisciplinary rehabilitation interventions for people with PD are particularly effective at improving QoL and motor function.18,10,11,5658 Although investment in such initiatives might prevent future costs attributed to disabling motor symptoms (eg, falls, loss of independence),58 innovative solutions should be considered to ensure such interventions can continue in the long-term, such as the Düsseldorf Parkinson network telemedicine care program. Not only do telemedicine approaches offer cost savings, they also have the benefit of opening up multidisciplinary care for people with PD who have limited access to specialist centers.59 While there are few studies of telemedicine in PD, schemes are on the increase enabling a better standard of care for patients in their homes or in remote areas.59,60 Furthermore, valid remote assessments of people with PD have been performed, and a high degree of patient satisfaction was reported with these studies.59,60

There is no “one-size-fits-all” approach to multidisciplinary care for people with PD; however, the models and studies discussed in this review may be adapted on a country/region/area basis. In countries lacking specialist MD services, a smaller, more localized MDT may be more realistic, with skilled physicians, who have experience in PD, initiating advanced therapies. Flexibility around implementing such approaches will increase access to multidisciplinary care for more people with PD, subsequently improving disease management, and ultimately patient and caregiver QoL.


Limitations of this review include the lack of a systematic literature search to identify relevant studies. Furthermore, very few published, controlled studies exist to quantify the effect on multidisciplinary interventions in PD. Finally, there is a lack of clinical guidelines in the subject area; hence, the recommendations provided here are informed by the clinical experience of the authors.


The advantages of an MDT approach are clear and have been documented in several small studies, but larger scale, controlled trials are required to fully understand the benefits. Given the chronic nature of PD, and the difficulties many patients face traveling to appointments, particularly those with advanced disease, it is imperative that future studies consider innovative approaches to enable wider access to MDT care.

Based on the available literature and expert clinical experience of authors, key recommendations for the MDT approach for people with PD are:

  1. to set up a close structured collaboration of different health care professionals working in a fixed network structure;

  2. to refer people with PD to established MDT centers (where available) in a timely manner;

  3. to establish regular meetings with treatment-responsible doctors and the MDT for interdisciplinary exchange and learning to optimize individual treatment and evaluate treatment options;

  4. to ensure treatment decisions are agreed jointly between people with PD, their caregiver, family, and health care professional;

  5. to include specialists outside of neurology from adjuvant medical departments as necessary when implementing advanced therapies.

Finally, the PDNS, a robust practical protocol that states who is doing what and when, and an effective network involving the community neurologist for training or consultation purposes are also pivotal to the success of the PD MDT.


This review was funded by AbbVie Inc., North Chicago, IL, USA. AbbVie participated in the writing, reviewing, and approving this paper. No payments were made to the authors for the development of this manuscript, and all authors approved the final version. Lindy van den Berghe and Emma East of Lucid Group, Burleighfield House, Buckinghamshire, UK, provided medical writing and editorial support to the authors in the development of this manuscript; financial support for these services was provided by AbbVie.


Pederson SW is a member of advisory boards for Ipsen, Allergan, Almira, Abbott, AbbVie, Sativex and has no share porfolio in medical companies. PSW also received lecture grants from Ipsen, AbbVie. van Laar T has received speaker fees from Britannia Pharmaceuticals, AbbVie, and Medtronic and also a research grant from AbbVie. Suedmeyer M has received grants and/or honoraria for consultancy from Teva, Medtronic, St Jude Medical, Novartis, Meda, and Abbvie. Liu LWC acts as a speaker and is on the advisory board of Abbvie, Allergan Canada, Takeda, and Actavis. Domagk D has received honoraria for lectures from Olympus and consultancy fees from Hitachi Medical Systems and AbbVie. Forbes A is an independent consultant PDNS to AbbVie. Onuk K, Bergmann L, and Yegin A are employees of AbbVie, holding stock/stock options. The authors report no other conflicts of interest in this work.



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