The relationship between serum-free insulin-like growth factor-1 and metabolic syndrome in school adolescents of northeast China
Received 22 November 2018
Accepted for publication 30 January 2019
Published 5 March 2019 Volume 2019:12 Pages 305—313
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Professor Ming-Hui Zou
Shuang Xie,1,2 Ranhua Jiang,3 Wanfeng Xu,4 Yu Chen,4 Lei Tang,1 Ling Li,1 Ping Li4
1Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, P.R. China; 2Department of General Medicine (VIP ward), Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning Province, P.R. China; 3Department of Endocrinology, Liaoyang Diabetes Hospital, Liaoyang, Liaoning Province, P.R. China; 4Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, P.R. China
Purpose: Free insulin-like growth factor-1 (IGF-1) ratio (the ratio of IGF-1/insulin-like growth factor binding protein-3 [IGFBP-3]) was shown to be negatively correlated with metabolic syndrome (MetS) in adults, but it was unknown in Chinese adolescents.
Patients and methods: The cross-sectional study enrolled 701 healthy school students (aged 12–16 years, 46.1% females) and 93 of them (18–22 years old, 46.2% females) were followed after 5 years.
Results: In the cross-sectional study, the IGF-1/IGFBP-3 ratios were found correlated with low-density lipoprotein cholesterol (LDL-C; r= -0.071, P<0.05) and diastolic blood pressure (r= -0.077, P=0.034). A lower IGF-1/IGFBP-3 ratio was an independent risk factor for MetS (OR =2.348, 95% CI: 1.040–5.303), hypertension (OR=1.729, 95% CI: 1.040–5.303), and increased LDL-C (OR=1.841, 95% CI: 1.230–2.755). In the follow-up study, all the participants were >18 years old. We found a lower baseline ratio of IGF-1/IGFBP-3 in adolescence was an independent risk factor for MetS in adulthood (OR=10.724, 95% CI: 1.032–11.403) and also indicated a higher body mass index (β=-1.361, 95% CI: -2.513 to -0.208) after 5 years.
Conclusion: The lower IGF-1/IGFBP-3 ratio was an independent risk factor for MetS, hypertension, and high LDL-C in adolescents of northeast China and was also a predictive marker for MetS and increased body mass index in the adulthood.
Keywords: IGF-1, IGFBP-3, adolescent, metabolic syndrome
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