Back to Journals » Neuropsychiatric Disease and Treatment » Volume 11

The reduction of volume and fiber bundle connections in the hippocampus of EGR3 transgenic schizophrenia rats

Authors Ma E, Song T, Zhang H, Lu J, Wang L, Zhao Q, Guo R, Li M, Ma G, Lu G, Li K

Received 23 January 2015

Accepted for publication 27 March 2015

Published 1 July 2015 Volume 2015:11 Pages 1625—1638


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder

Ensen Ma,1,2,* Tianbin Song,3,* Hui Zhang,4,* Jie Lu,5 Liwen Wang,2 Qichao Zhao,2 Runcai Guo,2 Miao Li,2 Guolin Ma,2 Guangming Lu,1 Kefeng Li6,7

1Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, People’s Republic of China; 2Department of Radiology, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 3Department of Radiology, Beijing Shunyi Hospital, Beijing, People’s Republic of China; 4Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, People’s Republic of China; 5Department of Radiology, Xuanwu Hospital of Capital Medical University, Xicheng, Beijing, People’s Republic of China; 6School of Medicine, University of California, San Diego, CA, USA; 7Tianjin SunnyPeak Biotech Co., Ltd, Tianjin, People’s Republic of China

*These authors contributed equally to this work

Background and objective: There is a growing consensus that schizophrenia is ultimately caused by abnormal communication between spatially disparate brain structures. White matter fasciculi represent the primary infrastructure for long distance communication in the brain. In this study, we aimed to investigate the white matter connection in schizophrenia susceptible brain regions of early growth response factor 3 (EGR3) expressing rats.
Methods: A rat model of schizophrenia was created by the transfection of the EGR3 gene into rat hippocampus. All animals were placed in a fixation system using a commercial rat-dedicated coil. Schizophrenia susceptible brain regions were scanned using in vivo diffusion tensor magnetic resonance imaging. The volume, quantity, average length of fiber bundles, fractional anisotropy, apparent diffusion coefficient, the relative heterosexual fraction, and volume ratio were collected in the whole brain and schizophrenia related brain areas (the hippocampus, thalamus, and prefrontal lobe). MedINRIA software was used for data processing of diffusion tensor and fiber bundles tracking. The fibronectin in relevant brain regions was also analyzed.
Results: There was a significant decrease in the volume of the fiber beam through the left hippocampus dentate in the schizophrenia model group in comparison to the control group and the risperidone treatment group (P<0.05). A significant reduction in the volume and number of the fiber bundles was also observed in left prefrontal–left hippocampus, left hippocampus–left thalamus, left prefrontal–left hippocampus–left thalamus areas in the model group (all P<0.05).
Conclusion: The volume of hippocampus and the number of fiber bundles were reduced in EGR3 transgenic schizophrenia rats, and are the most sensitive indicators in schizophrenia. The diffusion tensor imaging technique plays an important role in the evaluation of patients with schizophrenia.

Keywords: magnetic resonance imaging, schizophrenia, early growth response factor 3, fractional anisotropy, diffusion tensor imaging

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

The regional neuronal activity in left posterior middle temporal gyrus is correlated with the severity of chronic aphasia

Li J, Du D, Gao W, Sun X, Xie H, Zhang G, Li J, Li H, Li K

Neuropsychiatric Disease and Treatment 2017, 13:1937-1945

Published Date: 20 July 2017

Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction

Cui A, Zhang Y, Li J, Song T, Liu X, Wang H, Zhang C, Ma G, Zhang H, Li K

Drug Design, Development and Therapy 2017, 11:1243-1253

Published Date: 18 April 2017

ROI for outlining an entire tumor is a reliable approach for quantification of lung cancer tumor vascular parameters using CT perfusion

Ma E, Ren A, Gao B, Yang M, Zhao Q, Wang W, Li K

OncoTargets and Therapy 2016, 9:2377-2384

Published Date: 27 April 2016

Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010