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The prognostic value and mechanisms of lncRNA UCA1 in human cancer

Authors Yao F, Wang Q, Wu Q

Received 4 January 2019

Accepted for publication 29 May 2019

Published 14 August 2019 Volume 2019:11 Pages 7685—7696

DOI https://doi.org/10.2147/CMAR.S200436

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Rituraj Purohit


Fei Yao,1 Qiang Wang,1 Qingming Wu1,2

1Department of Public Health and Preventive Medicine, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, People’s Republic of China; 2Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, People’s Republic of China

Abstract: Long noncoding RNAs (lncRNAs), longer than 200 nucleotides in length, play important roles in the development and progression of various cancers. An increasing number of studies have revealed that lncRNAs function as potential oncogenes or tumor suppressors to influence biological processes, such as cell growth, invasion, migration and apoptosis. Urothelial carcinoma associated 1 (UCA1), an oncogenic lncRNA, was first found in bladder cancer and highly expressed in multiple cancers, including gastric cancer, colorectal cancer, lung cancer and breast cancer. UCA1 promotes tumorigenesis mainly via binding to tumor-suppressive microRNAs (miRNAs), activating several pivotal signaling pathways and alteration of epigenetic and transcriptional regulation. In addition, high expression of UCA1 is related to poor clinicopathological features especially for shorter overall survival, suggesting that UCA1 might be regarded as a prognosis biomarker in human cancers. In the present review, we summarized current studies on UCA1 to explore its prognostic value and underlying regulation mechanisms in the development of multiple cancers in order to provide a glimmer of hope for the prevention and treatment of malignant tumors.

Keywords: UCA1, lncRNA, cancer, prognostic, mechanism

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