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The prognostic roles of ALDH1 isoenzymes in gastric cancer

Authors Li K, Guo X, Wang Z, Li X, Bu Y, Bai X, Zheng L, Huang Y

Received 11 December 2015

Accepted for publication 10 March 2016

Published 7 June 2016 Volume 2016:9 Pages 3405—3414

DOI https://doi.org/10.2147/OTT.S102314

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 3

Editor who approved publication: Professor Min Li


Kai Li,1,2 Xiaoguang Guo,3 Ziwei Wang,4 Xiaofeng Li,2 Youquan Bu,5 Xuefeng Bai,6 Liansheng Zheng,7 Ying Huang2

1Hepatobiliary Treatment Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 2Department of Medical Oncology, 3Surgical Department, Baotou Cancer Hospital, Baotou, Inner Mongolia, 4Department of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing, 5Department of Biology, Chongqing Medical University, Chongqing, 6Department of Pathology, 7Surgical Oncology, Baotou Cancer Hospital, Baotou, Inner Mongolia, People’s Republic of China

Abstract: Increased aldehyde dehydrogenase 1 (ALDH1) activity has been determined to be present in the stem cells of several kinds of cancers including gastric cancer (GC). Nevertheless, which ones of ALDH1’s isoenzymes are leading to ALDH1 activity remains elusive. In this study, we examined the prognostic value and hazard ratio (HR) of individual ALDH1 isoenzymes in patients with GC using “The Kaplan–Meier plotter” database. mRNA high expression level of ALDH1A1 was not found to be significantly correlated with the overall survival (OS) of all patients with GC followed for 20 years, HR =0.86 (95% confidence interval [CI]: 0.7–1.05), P=0.13. mRNA high expression level of ALDH1A2 was also not significantly correlated with OS for all patients with GC, HR =1.13 (95% CI: 0.91–1.41), P=0.25. mRNA high expression level of ALDH1A3 was found to be significantly correlated with worsened OS in either intestinal-type patients, HR =2.24 (95% CI: 1.44–3.49), P=0.00026, or diffuse-type patients, HR =1.91 (95% CI: 1.02–3.59), P=0.04. Interestingly, mRNA high expression level of ALDH1B1 was found to be significantly correlated with better OS for all patients with GC, HR =0.66 (95% CI: 0.53–0.81), P=7.8e–05, and mRNA high expression level of ALDH1L1 was found to be significantly correlated with worsened OS for all patients with GC, HR =1.23 (95% CI: 1–1.51), P=0.048. Furthermore, our results also indicate that ALDH1A3 and ALDH1L1 are potential major contributors to the ALDH1 activity in GC, since mRNA high expression levels of ALDH1A3 and ALDH1L1 were found to be significantly correlated with worsened OS for all patients with GC. Based on our study, ALDH1A3 and ALDH1L1 are potential prognostic markers and therapeutic targets for patients with GC.

Keywords: KM plotter, cancer stem cell, ALDH1, hazard ratio, prognosis

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