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The preparation of metal–organic frameworks and their biomedical application

Authors Liu R, Yu T, Shi Z, Wang Z

Received 20 November 2015

Accepted for publication 12 January 2016

Published 23 March 2016 Volume 2016:11 Pages 1187—1200

DOI https://doi.org/10.2147/IJN.S100877

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Farooq Shiekh

Peer reviewer comments 4

Editor who approved publication: Dr Lei Yang

Rong Liu,1,2 Tian Yu,1 Zheng Shi,1 Zhiyong Wang3

1School of Medicine and Nursing, Chengdu University, Chengdu, 2Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, 3Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory for MRI, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of China

Abstract: The development of a safe and targetable drug carrier is a major challenge. An efficient delivery system should protect cargo from degradation and cleanup, and control of drug release in the target site. Metal–organic frameworks (MOFs), consisting of metal ions and a variety of organic ligands, have been applied for drug delivery due to their distinct structure. In this review, we summarized the synthesis strategies of MOFs, especially emphasizing the methods of pore creation in frameworks, which were based on recent literatures. Subsequently, the controlled size, biocompatibility, drug releasing performances, and imaging of MOFs were discussed, which would pave the road for the application in drug-delivery systems.

Keywords: metal-organic frameworks, pore creation, the controlled size, biocompatibility, drug releasing performances, imaging

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