Back to Journals » International Journal of Nanomedicine » Volume 11

The preparation of metal–organic frameworks and their biomedical application

Authors Liu R, Yu T, Shi Z, Wang Z

Received 20 November 2015

Accepted for publication 12 January 2016

Published 23 March 2016 Volume 2016:11 Pages 1187—1200

DOI https://doi.org/10.2147/IJN.S100877

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Farooq Shiekh

Peer reviewer comments 4

Editor who approved publication: Dr Lei Yang

Rong Liu,1,2 Tian Yu,1 Zheng Shi,1 Zhiyong Wang3

1School of Medicine and Nursing, Chengdu University, Chengdu, 2Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, 3Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory for MRI, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of China

Abstract: The development of a safe and targetable drug carrier is a major challenge. An efficient delivery system should protect cargo from degradation and cleanup, and control of drug release in the target site. Metal–organic frameworks (MOFs), consisting of metal ions and a variety of organic ligands, have been applied for drug delivery due to their distinct structure. In this review, we summarized the synthesis strategies of MOFs, especially emphasizing the methods of pore creation in frameworks, which were based on recent literatures. Subsequently, the controlled size, biocompatibility, drug releasing performances, and imaging of MOFs were discussed, which would pave the road for the application in drug-delivery systems.

Keywords: metal-organic frameworks, pore creation, the controlled size, biocompatibility, drug releasing performances, imaging

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Application of liposomal technologies for delivery of platinum analogs in oncology

Liu D, He C, Wang AZ, Lin W

International Journal of Nanomedicine 2013, 8:3309-3319

Published Date: 26 August 2013

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia

Hoeksema KA, Jayanthan A, Cooper T, Gore L, Trippett T, Boklan J, Arceci RJ, Narendran A

OncoTargets and Therapy 2011, 4:149-168

Published Date: 5 September 2011

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010