The power of the age standardized incidence rate to discover the gene link between cancer diseases: development of a new epidemiological method to save money, time, and effort for genetic scientists
Authors Alghamdi I, Hussain I, Alghamdi M, El-Sheemy M
Received 14 October 2014
Accepted for publication 7 January 2015
Published 31 March 2015 Volume 2015:8 Pages 677—687
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 3
Editor who approved publication: Dr Faris Farassati
Ibrahim G Alghamdi,1,2 Issam I Hussain,1 Mohamed S Alghamdi,3 Mohammed A El-Sheemy4
1School of Life Sciences, University of Lincoln, Lincoln, UK; 2College of Medicine, University of Al-Baha, Al-Baha, Saudi Arabia; 3Ministry of Health, General Directorate of Health Affairs Al-Baha, Al-Baha, Saudi Arabia; 4Lincoln Hospital, Research and Development United, Lincolnshire Hospitals NHS Trust, Lincoln, UK
Background: This study provides an incipient epidemiological rule using the concept of direct method of standardization to determine the genetic link between cancer diseases.
Methods: The overall 8 or 10 years age standardized incidence rate (ASIR) for both cancer diseases, for example (A) and (B) should be calculated for all regions of the country. A line chart should be used to display the overall ASIR trend of both diseases (A and B). Pearson’s correlation can be used to determine the strength of the association between the overall ASIRs of both diseases. The overlap or opposite direction of the overall ASIR trend of both diseases (A and B) should be determined and studied for possible associations between cancer diseases.
Results: If the trend of the overall 8 or 10 years ASIR of a disease (A) follows that of disease (B) in all regions of the country, then the genes of patients with both diseases (A and B) will be highly homogeneous, and they should be studied in the region with the highest and lowest overall ASIR for both diseases (A and B). In addition, if there is an opposite direction or overlapping trend for both diseases (A and B) in certain regions of the country or among specific groups of people with the same demographic characteristics, then the genes of patients will be investigated for both diseases to identify the potential gene link between cancer diseases.
Conclusion: This study revealed that the overall ASIR trends of female breast cancer, prostate cancer, and ovarian cancer are very similar in all regions of Saudi Arabia and England. Our epidemiological evidence helps to save money, time, and effort for testing the potential gene link between cancer diseases.
Keywords: epidemiology, medical statistics, direct standardization, England, Saudi Arabia
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