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The Potential Translational Applications of Nanoparticles in Endodontics

Authors Wong J, Zou T, Lee AHC, Zhang C

Received 24 November 2020

Accepted for publication 26 January 2021

Published 9 March 2021 Volume 2021:16 Pages 2087—2106


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Thomas J. Webster

Jasmine Wong, Ting Zou, Angeline Hui Cheng Lee, Chengfei Zhang

Restorative Dental Sciences (Endodontics), Faculty of Dentistry, The University of Hong Kong, Hong Kong Special Administrative Region

Correspondence: Chengfei Zhang
Restorative Dental Sciences (Endodontics), Faculty of Dentistry, The University of Hong Kong, Floor 3B60, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong Kong
Tel +852-2859-0371
Fax +852-2559-9013
Email [email protected]

Abstract: Nanotechnology has substantially progressed in the past decades, giving rise to numerous possible applications in different biomedical fields. In particular, the use of nanoparticles in endodontics has generated significant interest due to their unique characteristics. As a result of their nanoscale dimensions, nanoparticles possess several properties that may enhance the treatment of endodontic infections, such as heightened antibacterial activity, increased reactivity and the capacity to be functionalized with other reactive compounds. Effective disinfection and sealing of the root canal system are the hallmarks for successful endodontic treatment. However, the presence of bacterial biofilms and resistance to endodontic disinfectants pose a significant challenge to this goal. This has encouraged the investigation of antibacterial nanoparticle-based irrigants and intracanal medicaments, which may improve the elimination of endodontic infections. In addition, photosynthesizer-functionalized nanoparticles could also serve as a worthy adjunct to root canal disinfection strategies. Furthermore, despite the myriad of commercially available options for endodontic obturation, the “ideal” material has yet to be conceived. This has led to the development of various experimental nanoparticle-incorporated obturation materials and sealers that exhibit a range of favourable physicochemical properties including enhanced antibacterial efficacy and bioactivity. Nanoparticle applications also show promise in the field of regenerative endodontics, such as supporting the release of bioactive molecules and enhancing the biophysical properties of scaffolds. Given the constantly growing body of research in this field, this article aims to present an overview of the current evidence pertaining to the potential translational applications of nanoparticles in endodontics.

Keywords: nanoparticles, endodontics, translational research, disinfection, obturation, regenerative procedures

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