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The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders

Authors Peedicayil J

Received 12 December 2019

Accepted for publication 14 February 2020

Published 2 March 2020 Volume 2020:16 Pages 597—606

DOI https://doi.org/10.2147/NDT.S242040

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Jacob Peedicayil

Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, India

Correspondence: Jacob Peedicayil
Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, India
Tel/Fax +91-0416-2284237
Email jpeedi@cmcvellore.ac.in

Abstract: There is increasing evidence that abnormalities in epigenetic mechanisms of gene expression contribute to the pathogenesis of anxiety disorders (ADs). This article discusses the role of epigenetic mechanisms of gene expression in the pathogenesis of ADs. It also discusses the data so far obtained from preclinical and clinical trials on the use of epigenetic drugs for treating ADs. Most drug trials investigating the use of epigenetic drugs for treating ADs have used histone deacetylase inhibitors (HDACi). HDACi are showing favorable results in both preclinical and clinical drug trials for treating ADs. However, at present the mode of action of HDACi in ADs is not clear. More work needs to be done to elucidate how epigenetic dysregulation contributes to the pathogenesis of ADs. More work also needs to be done on the mode of action of HDACi in alleviating the signs and symptoms of ADs.

Keywords: anxiety disorders, epigenetic, histone deacetylase, histone deacetylase inhibitor

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