Back to Journals » Biologics: Targets and Therapy » Volume 2 » Issue 1

The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia

Authors Golombick T, Diamond T

Published 7 March 2008 Volume 2008:2(1) Pages 161—163

DOI https://doi.org/10.2147/BTT.S2514

Terry Golombick, Terry Diamond

Department of Endocrinology, St George Hospital, Kogarah, Australia

Abstract: Plasma cell dyscrasias, most commonly associated with paraproteinemia, are a diverse group of diseases. Monoclonal gammopathy of undefined significance (MGUS) can precede multiple myeloma, a progressive neoplastic disease. MGUS occurs in association with a variety of other diseases and currently no treatment is recommended but rather “watchful waiting”. Given that the size of the M-protein is a risk factor for disease progression, early intervention with the aim of reducing the paraprotein load would provide an innovative therapeutic tool. Preliminary results from our pilot study show a drop of between 5% and 30% serum paraprotein in patients taking curcumin compared with patients on placebo. Curcumin is a diferuloylmethane present in extracts of the rhizome of the Curcuma longa plant. As a natural product, this has exciting potential in the treatment of plasma cell dyscrasias.

Keywords: plasma cell dyscrasias, MGUS, myeloma, curcumin, paraproteinemia

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]