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The load and release characteristics on a strong cationic ion-exchange fiber: kinetics, thermodynamics, and influences

Authors Yuan J, Gao Y, Wang X, Liu H, Che X, Xu L, Yang Y, Wang Q, Wang Y, Li S

Received 21 March 2014

Accepted for publication 29 April 2014

Published 16 July 2014 Volume 2014:8 Pages 945—955

DOI https://doi.org/10.2147/DDDT.S64604

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Jing Yuan, Yanan Gao, Xinyu Wang, Hongzhuo Liu, Xin Che, Lu Xu, Yang Yang, Qifang Wang, Yan Wang, Sanming Li

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Abstract: Ion-exchange fibers were different from conventional ion-exchange resins in their non-cross-linked structure. The exchange was located on the surface of the framework, and the transport resistance reduced significantly, which might mean that the exchange is controlled by an ionic reaction instead of diffusion. Therefore, this work aimed to investigate the load and release characteristics of five model drugs with the strong cationic ion-exchange fiber ZB-1. Drugs were loaded using a batch process and released in United States Pharmacopoeia (USP) dissolution apparatus 2. Opposing exchange kinetics, suitable for the special structure of the fiber, were developed for describing the exchange process with the help of thermodynamics, which illustrated that the load was controlled by an ionic reaction. The molecular weight was the most important factor to influence the drug load and release rate. Strong alkalinity and rings in the molecular structures made the affinity between the drug and fiber strong, while logP did not cause any profound differences. The drug–fiber complexes exhibited sustained release. Different kinds and concentrations of counter ions or different amounts of drug–fiber complexes in the release medium affected the release behavior, while the pH value was independent of it. The groundwork for in-depth exploration and further application of ion-exchange fibers has been laid.

Keywords: ion-exchange fibers, ionic reaction, drug load and release, opposing exchange kinetics, thermodynamics, influences


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