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The genetic relationship between epilepsy and hemiplegic migraine
Authors Huang Y, Xiao H, Qin X, Nong Y, Zou D, Wu Y
Received 15 January 2017
Accepted for publication 23 March 2017
Published 24 April 2017 Volume 2017:13 Pages 1175—1179
DOI https://doi.org/10.2147/NDT.S132451
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 3
Editor who approved publication: Professor Wai Kwong Tang
Yiqing Huang,1 Hai Xiao,1 Xingyue Qin,1 Yuan Nong,1 Donghua Zou,2 Yuan Wu3
1Department of Neurology, Guigang City People’s Hospital and the Eighth Affiliated Hospital of Guangxi Medical University, Guigang, People’s Republic of China; 2Department of Neurology, The Fifth Affiliated Hospital of Guangxi Medical University and the First People’s Hospital of Nanning, Nanning, People’s Republic of China; 3Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China
Abstract: Epilepsy and migraine are common diseases of the nervous system and share genetic and pathophysiological mechanisms. Familial hemiplegic migraine is an autosomal dominant disease. It is often used as a model of migraine. Four genes often contain one or more mutations in both epilepsy and hemiplegic migraine patients (ie, CACNA1A, ATP1A2, SCN1A, and PRRT2). A better understanding of the shared genetics of epilepsy and hemiplegic migraine may reveal new strategic directions for research and treatment of both the disorders.
Keywords: epilepsy, migraine, CACNA1A, ATP1A2, SCN1A
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