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The etiologic origins for chronic obstructive pulmonary disease

Authors Huang X, Mu X, Deng L, Fu A, Pu E, Tang T, Kong X

Received 28 January 2019

Accepted for publication 18 April 2019

Published 27 May 2019 Volume 2019:14 Pages 1139—1158

DOI https://doi.org/10.2147/COPD.S203215

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Chunxue Bai


Xinwei Huang,1,2,* Xi Mu,3,* Li Deng,4 Aili Fu,5 Endong Pu,6 Tao Tang,2 Xiangyang Kong2

1Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming City, Yunnan Province, People’s Republic of China; 2Medical School, Kunming University of Science and Technology, Kunming City, Yunnan Province, People’s Republic of China; 3Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming City, Yunnan Province, People’s Republic of China; 4The Pathology Department, First People‘s Hospital of Yunnan Province, Kunming City, Yunnan Province, People’s Republic of China; 5Department of Oncology, Yunfeng Hospital, Xuanwei City, Yunnan Province, People’s Republic of China; 6Department of Thoracic Surgery, Yunfeng Hospital, Xuanwei City, Yunnan Province, People’s Republic of China

*These authors contributed equally to this work

Abstract: COPD, characterized by long-term poorly irreversible airway limitation and persistent respiratory symptoms, has resulted in enormous challenges to human health worldwide, with increasing rates of prevalence, death, and disability. Although its origin was thought to be in the interactions of genetic with environmental factors, the effects of environmental factors on the disease during different life stages remain little known. Without clear mechanisms and radical cure for it, early screening and prevention of COPD seem to be important. In this review, we will discuss the etiologic origins for poor lung function and COPD caused by specific adverse effects during corresponding life stages, as well as try to find new insights and potential prevention strategies for this disease.

Keywords: chronic obstructive pulmonary disease, COPD, early origins, risk factors, air pollution, cigarette smoking

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