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The emerging and diverse roles of sirtuins in cancer: a clinical perspective

Authors Yuan H, Su L, Chen W

Received 8 July 2013

Accepted for publication 5 September 2013

Published 8 October 2013 Volume 2013:6 Pages 1399—1416

DOI https://doi.org/10.2147/OTT.S37750

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

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Hongfeng Yuan,1 Leila Su,2 WenYong Chen1

1Department of Cancer Biology, 2Department of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, CA, USA

Abstract: Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-dependent protein lysine modifying enzymes with deacetylase, adenosine diphosphate-ribosyltransferase and other deacylase activities. Mammals have seven sirtuins, namely SIRT1-7. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development, aging, and cancer. Here we present an extensive literature review of the roles of mammalian sirtuins, particularly SIRT1 as that is the most studied sirtuin, in human epithelial, neuronal, hematopoietic, and mesenchymal malignancies, covering breast, prostate, lung, thyroid, liver, colon, gastric, pancreatic, ovarian, and cervical cancers, tumors of the central nervous system, leukemia and lymphoma, and soft tissue sarcomas. Collective evidence suggests sirtuins are involved in both promoting and suppressing tumorigenesis depending on cellular and molecular contexts. We discuss the potential use of sirtuin modulators, especially sirtuin inhibitors, in cancer treatment.

Keywords: sirtuin, cancer, sirtuin modulator, deacetylation, acetylation

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