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The diagnostic value of 99TcM-2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethyl dihydrogen phosphate hypoxia imaging and its evaluation performance for radiotherapy efficacy in non-small-cell lung cancer

Authors Yang Y, Han G, Xu W

Received 24 March 2016

Accepted for publication 14 June 2016

Published 21 October 2016 Volume 2016:9 Pages 6499—6509

DOI https://doi.org/10.2147/OTT.S109163

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Jia Fan

Peer reviewer comments 4

Editor who approved publication: Professor Min Li


Yongkun Yang, Gaohua Han, Wansong Xu

Department of Oncology, Taizhou People’s Hospital, Taizhou, Jiangsu, People’s Republic of China

Background and aim: This study was designated to assess the diagnostic value of 99TcM-2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethyl dihydrogen phosphate (99TcM-MNLS) hypoxia imaging and its evaluation performance for radiotherapy efficacy in patients with non-small-cell lung cancer (NSCLC).
Patients and methods: A total of 61 patients with NSCLC were selected for this study. All patients were injected with 99TcM-MNLS within 1 week prior to radiotherapy and they were injected with 99TcM-MNLS again 3 months after radiotherapy. Qualitative analysis along with semiquantitative analysis results were obtained from hypoxia imaging. Meanwhile, the effect of radiotherapy on patients with NSCLC was evaluated based on the solid tumor curative effect evaluation standard. Finally, SPSS 19.0 statistical software was implemented for statistical analysis.
Results: There was no significant difference in age or sex between the NSCLC patient group and benign patient group (P>0.05). 99TcM-MNLS was selectively concentrated in tumor tissues with a clear imaging in 24 hours. Results from both qualitative analysis and semiquantitative analysis indicated that the sensitivity and specificity of 99TcM-MNLS hypoxia imaging in diagnosing NSCLC were 93.8% and 84.6% and 72.9% and 100%, respectively. Moreover, the receiver operating characteristic curve provided evidence that 99TcM-MNLS hypoxia imaging was a powerful diagnostic tool in distinguishing malignant lung cancer from benign lesions. As suggested by 24-hour imaging, the tumor-to-normal ratio of patients in the 99TcM-MNLS high-intake group and low-intake group had a decline of 24.7% and 14.4% after radiotherapy, respectively. The decline in the tumor-to-normal ratio between the two dosage groups was significantly different (P<0.05).
Conclusion: 99TcM-MNLS hypoxia imaging had reliable values in both diagnosing NSCLC and evaluating therapeutic effects of radiotherapy on patients with NSCLC.

Keywords:
99TcM-MNLS hypoxia imaging, non-small-cell lung cancer, diagnosis, therapeutic effect evaluation, radiotherapy

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