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The Cumulative Incidence and Risk Factors of Recurrent Venous Thromboembolism in the Elderly

Authors Aleidan FAS

Received 27 May 2020

Accepted for publication 29 September 2020

Published 19 October 2020 Volume 2020:16 Pages 437—443

DOI https://doi.org/10.2147/VHRM.S264814

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Daniel A. Duprez


Fahad AS Aleidan1,2

1College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 2Anticoagulation Clinic, King Abdulaziz Medical City, Riyadh, Saudi Arabia

Correspondence: Fahad AS Aleidan
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Tel +966118011111
Email faleidan@gmail.com

Background: Incidence and outcomes of recurrent venous thromboembolism (VTE) in the elderly are still not fully elucidated. The purpose of this study was to determine the incidence and identify the risk factors of VTE recurrence in this population.
Methods: A prospective cohort study of a one-year follow-up of 277 patients aged ≥ 65 years with primary VTE was performed at King Abdulaziz Medical City, a tertiary care teaching hospital in Riyadh, Saudi Arabia. Demographic data, risk factors, and the consequences of VTE (recurrence, bleeding, and mortality) were recorded.
Results: Of the 277 VTE patients, 39 (14%) were diagnosed with recurrent VTE over a median follow-up period of 12 months. The cumulative incidence of recurrent VTE was 12.75 per hundred patient-year (95% CI, 8.24– 17.36). In multivariate Cox regression, malignancy (hazard ratio [HR], 2.87, 95% CI, 1.32– 6.24, p=0.008) and surgery (HR 2.78, 95% CI, 1.36– 5.67, p=0.005) were identified as independent risk factors for recurrent VTE. Metformin had a significant independent protection effect (HR, 0.16, 95% CI, 0.08– 0.33, p< 0.001). During follow-up, two patients in the recurrent VTE group and five patients in the group with no recurrent VTE, all of whom were minor bleeding cases, reported no major bleeding. Seven (18%) patients in the recurrent VTE group and nine (4%) patients in the group with no recurrent VTE died (p< 0.001).
Conclusion: The findings of this study show that elderly patients with initial VTE have a recurrent rate (14%), with a cumulative incidence rate of 12.75 per hundred patient-year. Malignancy and surgery were the most important clinical risk factors to impact significantly the development of recurrent VTE in our elderly population. Metformin may have a protective effect against recurrent VTE in the elderly population, and a larger study is needed to validate our findings.

Keywords: elderly, incidence, recurrence, risk factors, venous thromboembolism

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