Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

The COPD assessment test correlates well with the computed tomography measurements in COPD patients in China

Authors Zhang Y, Tu Y, Fei G

Received 9 November 2014

Accepted for publication 10 January 2015

Published 5 March 2015 Volume 2015:10(1) Pages 507—514


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell

Yan Zhang,* You-Hui Tu,* Guang-He Fei

Pulmonary Department, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China

*These authors contributed equally to this work

Background: The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is a validated simple instrument to assess health status, and it correlates well with the severity of airway obstruction in COPD patients. However, little is known about the relationships between CAT scores and quantitative computed tomography (CT) measurements of emphysema and airway wall thickness in COPD patients in the People’s Republic of China.
Methods: One hundred and twelve participants including 63 COPD patients and 49 normal control subjects were recruited. All participants were examined with high-resolution CT to get the measurements of emphysema (percentage of pixels below -950 HU [%LAA–950]) and airway wall thickness (wall area percentage and the ratio of airway wall thickness to total diameter). Meanwhile, they completed the CAT and modified Medical Research Council questionnaire independently.
Results: Significantly higher CAT scores and CT measurements were found in COPD patients compared with normal control subjects (P<0.05), and there was a tendency of higher CAT scores and CT measurements with increasing disease severity measured by GOLD staging system. Positive correlations were found between CAT scores and CT measurements (P<0.01). Using multiple linear stepwise regression, CAT score =-46.38+0.778× (wall area percentage) +0.203× (%LAA–950) (P<0.001). Meanwhile, CAT scores and CT measurements in COPD patients all positively correlated with the modified Medical Research Council grades and negatively correlated with FEV1% (P<0.01).
Conclusion: CAT scores correlate well with the quantitative CT measurements in COPD patients, which may provide an imaging evidence that the structural changes of the lungs in this disease are associated with the health status measured by CAT.

Keywords: chronic obstructive pulmonary disease, pulmonary function, quantitative computed tomography

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other article by this author:

Readers of this article also read:

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation

Liu DD, Pan H, He FW, Wang XY, Li JY, Yang XG, Pan WS

International Journal of Nanomedicine 2015, 10:6425-6434

Published Date: 13 October 2015

Safety of inhaled glycopyrronium in patients with COPD: a comprehensive analysis of clinical studies and post-marketing data

D’Urzo AD, Kerwin EM, Chapman KR, Decramer M, DiGiovanni R, D’Andrea P, Hu H, Goyal P, Altman P

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1599-1612

Published Date: 11 August 2015

Bronchoscopic lung volume reduction by endobronchial valve in advanced emphysema: the first Asian report

Park TS, Hong Y, Lee JS, Oh SY, Lee SM, Kim N, Seo JB, Oh YM, Lee SD, Lee SW

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1501-1511

Published Date: 29 July 2015

Supported self-management for patients with COPD who have recently been discharged from hospital: a systematic review and meta-analysis

Majothi S, Jolly K, Heneghan NR, Price MJ, Riley RD, Turner AM, Bayliss SE, Moore DJ, Singh SJ, Adab P, Fitzmaurice DA, Jordan RE

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:853-867

Published Date: 29 April 2015

Home-based pulmonary rehabilitation improves clinical features and systemic inflammation in chronic obstructive pulmonary disease patients

Nascimento ESP, Sampaio LMM, Peixoto-Souza FS, Dias FD, Gomes ELFD, Greiffo FR, Ligeiro de Oliveira AP, Stirbulov R, Vieira RP, Costa D

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:645-653

Published Date: 23 March 2015

Influence of indacaterol on daily physical activity in patients with untreated chronic obstructive pulmonary disease

Nishijima Y, Minami S, Yamamoto S, Ogata Y, Koba T, Futami S, Komuta K

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:439-444

Published Date: 27 February 2015

Functional capacity, physical activity, and quality of life in hypoxemic patients with chronic obstructive pulmonary disease

Saglam M, Vardar-Yagli N, Savci S, Inal-Ince D, Calik-Kutukcu E, Arikan H, Coplu L

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:423-428

Published Date: 26 February 2015

Tiotropium HandiHaler® and Respimat® in COPD: a pooled safety analysis

Halpin DMG, Dahl R, Hallmann C, Mueller A, Tashkin D

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:239-259

Published Date: 5 February 2015

Comorbidity and health-related quality of life in patients with severe chronic obstructive pulmonary disease attending Swedish secondary care units

Sundh J, Johansson G, Larsson K, Lindén A, Löfdahl CG, Janson C, Sandström T

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:173-183

Published Date: 22 January 2015