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The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer

Authors Li C, Fu X, He H, Chen C, Wang Y, He L

Received 11 January 2020

Accepted for publication 16 April 2020

Published 19 May 2020 Volume 2020:12 Pages 3673—3689


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Chien-Feng Li

Changjiu Li,1,* Xian Fu,2,* Huadong He,1 Chao Chen,2 Yuyong Wang,2 Lugeng He2

1Department of Urology, Affiliated Hangzhou First People’s Hospital, Nanjing Medical University, Hangzhou 310006, Zhejiang Province, People’s Republic of China; 2Department of Urology, Affiliated Hangzhou First People’s Hospital, Zhejiang University, Hangzhou 310006, Zhejiang Province, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Huadong He Tel +86 18058765837

Abstract: Bladder cancer (BCa) is the 10th most prevalent malignancy worldwide and remains a crucial cause of cancer-related morbidity and mortality. Circular RNAs (circRNAs), a large class of endogenous non-coding RNAs, contain unique covalent closed structures and their biogenesis and turnover are regulated by multiple factors. Recently, multiple circRNAs have been found to serve as important factors in several biological processes such as tumorigenesis. An increasing amount of research discovered that circRNAs are dysregulated in multiple cancer tissues compared with matched normal tissues, especially in BCa, indicating that circRNAs can act as biomarkers for the diagnosis and prognosis of BCa. In this review, we focus on the biogenesis, properties, turnover, and functions of circRNAs, summarizing their potential functions and clinical implications in BCa.

Keywords: circRNA, circular RNA, biogenesis, microRNA sponge, bladder cancer, biomarker

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