Back to Journals » Neuropsychiatric Disease and Treatment » Volume 15

The association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis

Authors Zhao L, Li X, Liu G, Han B, Wang J, Jiang X

Received 29 September 2018

Accepted for publication 18 January 2019

Published 12 March 2019 Volume 2019:15 Pages 675—684

DOI https://doi.org/10.2147/NDT.S189200

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Yu-Ping Ning


Lifeng Zhao,1 Xuesong Li,2 Guanying Liu,1 Baoling Han,1 Jian Wang,1 Xia Jiang1

1Department of Endocrinology, Tianjin First Center Hospital, Tianjin, China; 2First Center Clinical Medical Institute, Tianjin Medical University, Tianjin, China

Objective: Recent controversial evidence suggests that maternal diabetes may increase the risk of attention deficit and hyperactivity disorder (ADHD) in offspring. To examine this potential association, a systematic literature search and meta-analysis was performed.
Methods: OR or risk ratio (RR) from each study was obtained and combined for evaluating the risk. Six cohort studies and three case-control studies were included in the present study.
Results: The meta-analysis of the highly heterogeneous case-control studies did not find significant association between maternal diabetes and ADHD risk (OR: 1.20, 95% CI: 0.96–1.49). The combining of the cohort studies demonstrated that offspring of diabetic mothers were at higher risk of ADHD (RR: 1.40, 95% CI: 1.27–1.54); however, publication bias was identified. When exposure was specified as gestational diabetes mellitus (GDM), GDM exposure increased the risk of ADHD for children by 164% (95% CI: 1.25–5.56) in a Caucasian population. Neither heterogeneity nor publication bias was detected.
Conclusion: Maternal diabetes, especially GDM, is probably a risk factor for ADHD in the Caucasian population. More studies based on large sample size and different ethnicities are needed to confirm this association.

Keywords: maternal diabetes, attention deficit hyperactivity disorder, meta-analysis


Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]