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The association between cortisol:C-reactive protein ratio and depressive fatigue is a function of CRP rather than cortisol

Authors Sharpley CF, Bitsika V, McMillan ME, Jesulola E, Agnew LL

Received 29 April 2019

Accepted for publication 29 July 2019

Published 27 August 2019 Volume 2019:15 Pages 2467—2475

DOI https://doi.org/10.2147/NDT.S213839

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Yuping Ning


Christopher F Sharpley,1 Vicki Bitsika,1 Mary E McMillan,1 Emmanuel Jesulola,2 Linda L Agnew1

1Brain-Behaviour Research Group, University of New England, Armidale, NSW 2351, Australia; 2Emergency Department, Bathurst Base Hospital, Bathurst, NSW 2795, Australia

Correspondence: Christopher F Sharpley
Brain-Behaviour Research Group, University of New England, Queen Elizabeth Drive, Armidale, NSW 2350, Australia
Tel +61 26 773 2596
Email csharpl3@une.edu.au

Purpose: Hormonal and inflammatory factors have been suggested as potentially influencing depressive state and depressive symptoms, but rarely compared for their relative contribution to these states and to specific depressive symptoms. This study examined cortisol:C-reactive protein (CRP) ratio, plus cortisol and CRP separately, as correlates of global depression and fatigue-related depression.
Patients and methods: One hundred and twenty-six community volunteers from rural Australia provided saliva and serum samples, and also completed a depression inventory.
Results: There was a significant correlation between cortisol:CRP ratio and depression-related fatigue, and this resolved to the effects of CRP rather than cortisol. Most of the variance in this association came from patients who were “depressed”, and there were no significant gender associations.
Conclusion: Inflammation, rather than HPA-axis activity, was associated with depression-related fatigue, supporting a model that places inflammation as a contributor to one of the major symptoms and predictors of depression. Individualization of therapy for depression-related fatigue in chronically stressed or physically ill patients might benefit from future research into cytokine therapy.

Keywords: depression, fatigue, CRP, cortisol


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