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The association between CD157/BST1 polymorphisms and the susceptibility of Parkinson’s disease: a meta-analysis

Authors Li J, Luo J, Liu L, Fu H, Tang L

Received 15 October 2018

Accepted for publication 29 December 2018

Published 30 April 2019 Volume 2019:15 Pages 1089—1102

DOI https://doi.org/10.2147/NDT.S190935

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Professor Jun Chen


Jianming Li,1–3 Jia Luo,2 Li Liu,2 Hui Fu,2,3 Liang Tang2

1Department of Neurology, Xiang-ya Hospital, Central South University, Changsha 410219, People’s Republic of China; 2Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, 410219, People’s Republic of China; 3Department of Human Anatomy, School of Basic Medical Science, Changsha Medical University, Changsha, 410219, People’s Republic of China

Background: Different studies have provided some evidence for the association between BST1 polymorphisms and Parkinson’s disease (PD). The extent to which these genetic effects are consistent across different populations is unknown.
Methods: A meta-analysis of PD case-control studies using a common set of three variants was conducted. Published reports were obtained from electronic databases including Pubmed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Cochrane Library databases between August 2010 and January 2018.
Results: A total of 11 individual studies with 8,725 cases and 17,079 controls were included. The results showed statistically significant association between the dominant model of rs11931532 and PD risk in Asian populations (P=0.006, OR [95% CI]=1.22 [1.06–1.41]). Significant association was also detected between the allelic, dominant, and recessive models of rs4698412 and PD risk in Asian populations (allelic model: P<0.00001, OR [95% CI]=1.22 [1.16–1.29]; dominant model: P<0.00001, OR [95%CI]=1.35 [1.20–1.52]; recessive model; P=0.0003, OR [95% CI]=1.30 [1.13–1.50]). Nevertheless, the pooled analyses suggested that no significant association was uncovered between rs11724635 and PD risk (P>0.05).
Conclusion: The meta-analysis suggests that the rs11931532 and rs4698412, but not rs11724635 might be risk factors for PD in Asian populations.

Keywords: BST1, Parkinson’s disease, polymorphisms, risk factor


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