Back to Journals » Drug Design, Development and Therapy » Volume 12

Tendinopathy: injury, repair, and current exploration

Authors Lipman K, Wang CC, Ting K, Soo C, Zheng Z

Received 20 October 2017

Accepted for publication 31 January 2018

Published 20 March 2018 Volume 2018:12 Pages 591—603


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Georgios D. Panos

Kelsey Lipman,1 Chenchao Wang,2–4 Kang Ting,2 Chia Soo,4 Zhong Zheng2

1David Geffen School of Medicine, 2Division of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA; 3First Hospital of China Medical University, Shenyang, China; 4Division of Plastic and Reconstructive Surgery, Department of Orthopaedic Surgery, Orthopaedic Hospital Research Center, University of California, Los Angeles, CA, USA

Abstract: Both acute and chronic tendinopathy result in high morbidity, requiring management that is often lengthy and expensive. However, limited and conflicting scientific evidence surrounding current management options has presented a challenge when trying to identify the best treatment for tendinopathy. As a result of shortcomings of current treatments, response to available therapies is often poor, resulting in frustration in both patients and physicians. Due to a lack of understanding of basic tendon-cell biology, further scientific investigation is needed in the field for the development of biological solutions. Optimization of new delivery systems and therapies that spatially and temporally mimic normal tendon physiology hold promise for clinical application. This review focuses on the clinical importance of tendinopathy, the structure of healthy tendons, tendon injury, and healing, and a discussion of current approaches for treatment that highlight the need for the development of new nonsurgical interventions.

Keywords: tendinopathy, tendon injury, tendon repair, healing

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]