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Targeting energy metabolism to eliminate cancer cells

Authors Shahruzaman SH, Fakurazi S, Maniam S

Received 6 March 2018

Accepted for publication 13 April 2018

Published 31 July 2018 Volume 2018:10 Pages 2325—2335

DOI https://doi.org/10.2147/CMAR.S167424

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Jaya Mallela

Peer reviewer comments 3

Editor who approved publication: Dr Antonella D'Anneo


Shazwin Hani Shahruzaman, Sharida Fakurazi, Sandra Maniam

Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia

Abstract: Adaptive metabolic responses toward a low oxygen environment are essential to maintain rapid proliferation and are relevant for tumorigenesis. Reprogramming of core metabolism in tumors confers a selective growth advantage such as the ability to evade apoptosis and/or enhance cell proliferation and promotes tumor growth and progression. One of the mechanisms that contributes to tumor growth is the impairment of cancer cell metabolism. In this review, we outline the small-molecule inhibitors identified over the past decade in targeting cancer cell metabolism and the usage of some of these molecules in clinical trials.

Keywords: cancer metabolism, hypoxia, glycolysis, oxidative phosphorylation

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