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Targeting Cancer Stem Cells by Oncolytic Viruses and Nano-Mediated Delivery

Authors Hosseini M, Farassati FS, Farassati F

Received 1 September 2020

Accepted for publication 7 September 2020

Published 22 September 2020 Volume 2020:13 Pages 9349—9350

DOI https://doi.org/10.2147/OTT.S279639

Checked for plagiarism Yes


Mahsa Hosseini, Fatemeh S Farassati, Faris Farassati

Molecular Medicine Laboratory, Midwest Veterans Biomedical Research Foundation, Kansas City Veterans Affairs Medical Center, Kansas City, MO 64128, USA

Correspondence: Faris Farassati
Molecular Medicine Laboratory, Midwest Veterans Biomedical Research Foundation, Kansas City Veterans Affairs Medical Center, 4801 Linwood Blvd, Kansas City, MO 64128, USA
Email ffarassati@gmail.com


Cancer stem cells (CSCs) as targets for oncolytic virotherapy is a novel concept which involves direct infection of cancer stem cells resulting to their destruction and eventual destruction of the tumor.1,9 Oncolytic viruses include herpes simplex virus-1 (HSV-1), reovirus, adenovirus, vaccinia virus, myxoma virus, etc. replicate selectively in the cancer cells resulting their destruction without damaging normal cells.1
 
 

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