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Sustained co-delivery of ibuprofen and basic fibroblast growth factor by thermosensitive nanoparticle hydrogel as early local treatment of peri-implantitis

Authors Chen W, Zhi M, Feng Z, Gao P, Yuan Y, Zhang C, Wang Y, Dong A

Received 13 October 2018

Accepted for publication 17 January 2019

Published 21 February 2019 Volume 2019:14 Pages 1347—1358

DOI https://doi.org/10.2147/IJN.S190781

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Thiruganesh Ramasamy

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang


Wenlei Chen,1 Min Zhi,1 Zujian Feng,2 Pengfei Gao,1 Yuan Yuan,1 Congcong Zhang,1 Yonglan Wang,1 Anjie Dong2

1Department of Periodontology, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, People’s Republic of China; 2Department of Polymer Science and Technology and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of China

Objective: The aims of this study were to 1) encapsulate ibuprofen (IBU) and basic fibroblast growth factor (bFGF) in a thermosensitive micellar hydrogel, 2) test the biological properties of this in situ drug delivery system, and 3) study the effect of hydrogel in promoting soft tissue healing after implant surgery and its anti-inflammatory function as an early local treatment of peri-implantitis.
Materials and methods: A thermosensitive micellar hydrogel was prepared from amphiphilic copolymer poly(ε-caprolactone-co-1,4,8-trioxa [4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(ε-caprolactone-co-1,4,8-trioxa [4.6]spiro-9-undecanone) (PECT) nanoparticles and tested in vitro using a scanning electron microscope, rheometer, UV spectrophotometer, HPLC, and transmission electron microscope.
Results: The bFGF + IBU/PECT hydrogel formed a stable, water-dispersible nanoparticle core shell that was injectable at room temperature, hydrogel in situ at body temperature, and provided sustained release of both hydrophilic and hydrophobic drugs. The hydrogel promoted the proliferation and adhesion of human gingival fibroblasts, upregulated the expression of adhesion factors such as vinculin proteins, and showed anti-inflammatory properties.
Conclusion: In situ preparation of IBU- and bFGF-loaded PECT hydrogel represents a promising drug delivery system with the potential to provide early local treatment for peri-implantitis.

Keywords: thermosensitive hydrogel, nanoparticles, dual drugs, peri-implantitis
 

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