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Successful treatment of relapsed testicular embryonal rhabdomyosarcoma with Endostar and traditional chemotherapy: a case report

Authors Han T, Chen JJ, Luan YT, Chen XX, Yang XD, Zhang Y, Li G, Wang D, Zheng ZD

Received 3 April 2018

Accepted for publication 6 July 2018

Published 30 August 2018 Volume 2018:11 Pages 5287—5291

DOI https://doi.org/10.2147/OTT.S170008

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 5

Editor who approved publication: Dr Samir Farghaly


Tao Han,1,* Jianjun Chen,1,* Yuting Luan,2,* Xiaoxia Chen,1,* Xiaodan Yang,1 Yue Zhang,1 Gao Li,2 Di Wang,3 Zhendong Zheng1

1Department of Oncology, Cancer Center of People’s Liberation Army, General Hospital of Shenyang Military Region, Shenyang 110840, People’s Republic of China; 2Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang 110840, People’s Republic of China; 3Department of Pathology, General Hospital of Shenyang Military Region, Shenyang 110840, People’s Republic of China

*These authors contributed equally to this work

Abstract: Embryonal rhabdomyosarcoma (ERMS) has a low prevalence, poor prognosis, and limited treatment efficacy. We report a case of an 18-year-old male whose disease relapsed in the abdominal cavity after a testicular ERMS curative resection. The patient received eight sequential cycles of rescue therapy using cisplatin and isocyclophosphamide in combination with a vascular targeted drug, Endostar. The therapeutic effect of the combination regimen has been evaluated for complete response. This is the first case to report using Endostar and chemotherapy in relapsed ERMS, and the curative effect results in complete response. Endostar, a new vascular targeted drug, combined with chemotherapy may play a synergistic role and provide a reference for the treatment of ERMS.

Keywords: embryonal rhabdomyosarcoma, metastasis, complete response, endogenous angiogenesis inhibitor

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