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Successful treatment of paraganglioma with sorafenib: a case report and brief review of the literature

Authors Lin Y, Li Q, Huang W, Jia X, Jiang H, Gao Y, Li Q

Received 31 August 2013

Accepted for publication 12 October 2013

Published 5 November 2013 Volume 2013:6 Pages 1559—1562

DOI https://doi.org/10.2147/OTT.S53813

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Yun Lin,1,* Qun Li,1,* Wei Huang,1 Xinyan Jia,1 Hong Jiang,1 Yong Gao,1 Qi Li1,2

1Department of Oncology, Shanghai East Hospital, 2Department of Oncology, Shanghai First People's Hospital, Shanghai, People's Republic of China

*These authors contributed equally to this work, and are joint first authors

Introduction: To date, no effective systemic therapies have been made available for paraganglioma. However, multiple mutations in susceptibility genes have been identified that are potential targets for sorafenib, an oral multitargeted tyrosine-kinase inhibitor.
Case presentation: We report the case of a 69-year-old Chinese man with mediastinal paraganglioma that had metastasized to the bone. The paraganglioma responded to sorafenib, a novel multi-tyrosine kinase inhibitor that targets angiogenesis, the Raf-kinase pathway, the platelet-derived growth factor Ret, and c-Kit. The patient was diagnosed as having paraganglioma after biopsy of the mediastinal mass. We first treated the patient with radiotherapy. Then he tolerated an etoposide-and-cisplatin chemotherapy regimen. Subsequently, he received 6 months of maintenance treatment with sorafenib (400 mg twice daily). A dramatic reduction in tumor volume was observed. At present, the patient has achieved a partial response, and his clinical status remains unchanged.
Conclusion: We suggest that sorafenib should be further investigated in the management of patients with paraganglioma.

Keywords: sorafenib, paraganglioma, molecular-targeted drug

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