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Subacute sclerosing panencephalitis – current perspectives

Authors Jafri SK, Kumar R, Ibrahim SH

Received 21 August 2017

Accepted for publication 19 February 2018

Published 26 June 2018 Volume 2018:9 Pages 67—71

DOI https://doi.org/10.2147/PHMT.S126293

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Roosy Aulakh


Sidra K Jafri, Raman Kumar, Shahnaz H Ibrahim

Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan

Abstract: Subacute sclerosing panencephalitis is a progressive neurodegenerative disease. It usually occurs 7–10 years after measles infection. The clinical course is characterized by progressive cognitive decline and behavior changes followed by focal or generalized seizures as well as myoclonus, ataxia, visual disturbance, and later vegetative state, eventually leading to death. It is diagnosed on the basis of Dyken’s criteria. There is no known cure for subacute sclerosing panencephalitis to date, but it is preventable by ensuring that an effective vaccine program for measles is made compulsory for all children younger than 5 years in endemic countries.

Keywords: SSPE, progressive, vaccine, preventable

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