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Strengthening the case that elevated levels of programmed death ligand 1 predict poor prognosis in hepatocellular carcinoma patients

Authors Zhong J, Luo C, Zhang C, Li L

Received 20 September 2016

Accepted for publication 11 November 2016

Published 30 December 2016 Volume 2017:4 Pages 11—13

DOI https://doi.org/10.2147/JHC.S122807

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Ahmed Kaseb


Jian-Hong Zhong,1,* Cheng-Piao Luo,2,* Chun-Yan Zhang,2 Le-Qun Li1

1Hepatobiliary Surgery Department, 2Experimental Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, People’s Republic of China

*These authors contributed equally to this work

Abstract: Immunotherapy targeting programmed death receptor 1 and programmed death ligand 1 (PD-L1) has shown impressive antitumor efficacy in several solid cancers, including advanced hepatocellular carcinoma (HCC). Since response rates of various cancers to such immunotherapy appear to correlate with PD-L1 expression levels, several studies have examined whether PD-L1 expression correlates with HCC pathology and patient prognosis. In this paper, we analyzed the strength and limitations of a recent meta-analysis of associations of PD-L1 with HCC characteristics and patient prognosis.

Keywords: hepatocellular carcinoma, programmed death ligand 1, hepatic resection, prognoses

Acknowledgments

This work was funded by the National Natural Science Foundation of the People’s Republic of China (81560460, 81060173), Guangxi University of Science and Technology Research Projects (KY2015LX056), the Self-Raised Scientific Research Fund of the Ministry of Health of Guangxi Province (Z2015621, Z2015601, GZZC15-34), and the Innovation Project of Guangxi Graduate Education (YCBZ2015030). The funding source had no role in the design or conduct of the study; in the collection, analysis, or interpretation of the data; or in the preparation, review, or approval of the manuscript.

Disclosure

The authors report no conflicts of interest in this work.

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