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Statin use and mortality of patients with prostate cancer: a meta-analysis

Authors Meng Y, Liao Y, Xu P, Wei W, Wang J

Received 10 October 2015

Accepted for publication 20 January 2016

Published 21 March 2016 Volume 2016:9 Pages 1689—1696

DOI https://doi.org/10.2147/OTT.S97993

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 3

Editor who approved publication: Professor Daniele Santini


Yang Meng,1,* Yan-Biao Liao,2,* Peng Xu,1 Wu-Ran Wei,1 Jia Wang1

1Department of Urology, 2Department of Cardiology, West China Hospital of Sichuan University, Chengdu, People’s Republic of China

*These authors contributed equally to this work

Objective: The aim of this meta-analysis was to investigate the effect of statin use on the mortality of patients with prostate cancer (PCa).
Methods: An electronic search of PubMed, Embase, and CENTRAL databases from inception to August 2015 was performed to find eligible studies. Articles investigating the association between statin use and mortality of PCa were identified. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using random- or fixed-effects models.
Results: In total, 13 studies that enrolled 100,536 participants were included in this meta-analysis. Results showed that prediagnostic statin use had a significantly lower risk of both all-cause mortality (ACM; HR, 0.56; 95% CI, 0.38–0.83) and PCa-specific mortality (PCSM; HR, 0.53; 95% CI, 0.36–0.77). Similarly, postdiagnostic statin use was correlated with reductions in both ACM (HR, 0.77; 95% CI, 0.69–0.87) and PCSM (HR, 0.64; 95% CI, 0.52–0.79). When stratified by primary treatment, postdiagnostic use of statins had a 0.4-fold lower risk of ACM in patients with PCa who were treated with local therapy; both pre- and postdiagnostic use of statins was correlated with a significantly lower risk of PCSM in patients who were treated with androgen deprivation therapy.
Conclusion: Both pre- and postdiagnostic use of statins is associated with better overall survival and PCa-specific survival. This suggests a need for randomized controlled trials of statins in patients with PCa.

Keywords: prostate cancer, all-cause mortality, prostate cancer-specific mortality, statins

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