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Spotlight on bevacizumab in metastatic colorectal cancer: patient selection and perspectives

Authors Bupathi M, Ahn D, Bekaii-Saab T

Received 26 March 2016

Accepted for publication 28 April 2016

Published 30 June 2016 Volume 2016:6 Pages 21—30

DOI https://doi.org/10.2147/GICTT.S97740

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Eileen O'Reilly


Manojkumar Bupathi, Daniel H Ahn, Tanios Bekaii-Saab

Department of Medical Oncology, Richard Solove Research Institute and James Cancer Hospital, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Abstract: Metastatic colorectal cancer (mCRC) is a prevalent disease for which combination cytotoxic chemotherapy is the mainstay of treatment. With the use of targeted therapy, including anti-angiogenic agents, there have been significant improvements in overall outcome of patients with mCRC. Bevacizumab, a monoclonal antibody targeting the vascular endothelial growth factor ligand A, is approved for use in mCRC patients in both the first and second lines of therapy. With a better understanding of the disease through molecular profiling, identification of prognostic biomarkers may lead to better patient selection with improved outcomes for those affected by this disease.

Keywords: VEGF, colon, rectum, cancer

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