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SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy?

Authors Sun L, Li S, Guo Q, Zhou W, Zhang H

Received 14 February 2020

Accepted for publication 22 April 2020

Published 18 May 2020 Volume 2020:12 Pages 3561—3569

DOI https://doi.org/10.2147/CMAR.S249754

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Yong Teng


Li-rui Sun,1,* Si-yu Li,2,* Qiu-shi Guo,1 Wei Zhou,1 Hong-mei Zhang1

1Department of Pharmacy, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of Pathology, Hangzhou Third Hospital, Hangzhou, Zhejiang, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Wei Zhou; Hong-mei Zhang
Department of Pharmacy, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China
Email zhouweiyjk@163.com; zhmjyk@163.com

Background: Cancer metastasis is the main obstacle to increasing the lifespan of cancer patients. Epithelial-to-mesenchymal transition (EMT) plays a significant role in oncogenic processes, including tumor invasion, intravasation, and micrometastasis formation, and is especially critical for cancer invasion and metastasis. The extracellular matrix (ECM) plays a crucial role in the occurrence of EMT corresponding to the change in adhesion between cells and matrices.
Conclusion: SPOCK1 is a critical regulator of the ECM and mediates EMT in cancer cells. This suggests an important role for SPOCK1 in tumorigenesis, migration and invasion. SPOCK1 is a critical regulator of some processes involved in cancer progression, including cancer cell proliferation, apoptosis and migration. Herein, the functions of SPOCK1 in cancer progression are expounded, revealing the association between SPOCK1 and EMT in cancer metastasis. SPOCK1 is a positive downstream regulator of transforming growth factor-β, and SPOCK1-mediated EMT regulates invasion and metastasis through the Wnt/β-catenin pathway and PI3K/Akt signaling pathway. It is of significance that SPOCK1 may be an attractive prognostic biomarker and therapeutic target in cancer treatment.

Keywords: SPOCK1, epithelial-to-mesenchymal transition, extracellular matrix, cancer, metastasis

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