Sleep problems during the menopausal transition: prevalence, impact, and management challenges
Authors Baker FC, de Zambotti M, Colrain IM, Bei B
Received 15 September 2017
Accepted for publication 6 December 2017
Published 9 February 2018 Volume 2018:10 Pages 73—95
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Prof. Dr. Roumen Kirov
Peer reviewer comments 2
Editor who approved publication: Professor Steven A Shea
Fiona C Baker,1,2 Massimiliano de Zambotti,1 Ian M Colrain,1,3 Bei Bei4,5
1Center for Health Sciences, SRI International, Menlo Park, CA, USA; 2Brain Function Research Group, University of the Witwatersrand, Johannesburg, South Africa; 3Melbourne School of Psychological Sciences, University of Melbourne, 4Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, 5Centre for Women’s Mental Health, Department of Psychiatry, University of Melbourne, Royal Women’s Hospital, Melbourne, VIC, Australia
Abstract: A substantial number of women experience sleep difficulties in the approach to menopause and beyond, with 26% experiencing severe symptoms that impact daytime functioning, qualifying them for a diagnosis of insomnia. Here, we review both self-report and polysomnographic evidence for sleep difficulties in the context of the menopausal transition, considering severity of sleep complaints and links between hot flashes (HFs) and depression with poor sleep. Longitudinal population-based studies show that sleep difficulties are uniquely linked with menopausal stage and changes in follicle-stimulating hormone and estradiol, over and above the effects of age. A major contributor to sleep complaints in the context of the menopausal transition is HFs, and many, although not all, HFs are linked with polysomnographic-defined awakenings, with HF-associated wake time contributing significantly to overall wakefulness after sleep onset. Some sleep complaints may be comorbid with depressive disorders or attributed to sleep-related breathing or movement disorders, which increase in prevalence especially after menopause, and for some women, menopause, age, and environmental/behavioral factors may interact to disrupt sleep. Considering the unique and multifactorial basis for sleep difficulties in women transitioning menopause, we describe clinical assessment approaches and management options, including combination treatments, ranging from cognitive behavioral therapy for insomnia to hormonal and nonhormonal pharmacological options. Emerging studies suggest that the impact of severe insomnia symptoms could extend beyond immediate health care usage and quality of life issues to long-term mental and physical health, if left untreated in midlife women. Appropriate treatment, therefore, has immediate benefit as well as advantages for maintaining optimal health in the postmenopausal years.
Keywords: insomnia, midlife women, hormone therapy, estradiol, hot flashes, vasomotor symptoms
Menopause, defined by cessation of menses, marks an important transition in reproductive states in women. The menopausal transition, which begins 4–6 years before cessation of menses (occurring at a median age of 51 years), is associated with fluctuating hormone levels and emergence of physiological and psychological symptoms such as hot flashes (HFs), sleep disturbances, mood changes, and vaginal dryness. Symptoms vary between women in frequency, severity, and duration, persisting for several years after menopause in some women. Sleep disturbances are a major complaint of women transitioning menopause1–5 and have a far-reaching impact on the quality of life, mood, productivity, and physical health, especially in women in whom sleep disturbances are severe and associated with functional impairment. In this review, we discuss sleep-related issues that arise during the menopausal transition, considering subclinical changes in sleep quality as well as severe sleep disturbances that qualify women for insomnia disorder. We discuss the role of HFs in disrupting sleep, links between depression and sleep disturbance, and the potential impact of chronic sleep disturbance on health in midlife women. Finally, we discuss strategies for managing insomnia in the context of menopause.
Defining the menopausal transition
The menopausal transition refers to the years leading up to menopause, or final menstrual period, when endocrinological, biological, and clinical features of approaching menopause commence.6 The median age of onset of the menopausal transition is 47 years, and the median age at final menstrual period is 51.4 years.7 The Stages of Reproductive Aging Workshop (STRAW)8 (updated in 20119) is considered the gold standard for characterizing reproductive aging, broadly grouping women into three categories (reproductive, menopausal transition, and postmenopause) with further subdivisions defined by bleeding criteria and hormone levels (Figure 1).
Figure 1 Progression through the menopausal transition and postmenopause as defined by the Stages of Reproductive Aging Workshop (STRAW).
Notes: Schematic changes in follicle-stimulating hormone and estradiol (follicular phase samples) are superimposed on the STRAW criteria, although there is substantial variability in hormone levels across the transition. Menstrual cycle-related fluctuations in hormones are shown in the insert. Data from Soules et al and Harlow.8,9
Abbreviations: FSH, follicle-stimulating hormone; LH, luteinizing hormone; STRAW, Stages of Reproductive Aging Workshop.
The early menopausal transition is marked by a persistent difference of ≥7 days in the length of consecutive cycles.9 The late menopausal transition is marked by increased variability in cycle length and the occurrence of amenorrhea of ≥60 days.9 Hormonal changes roughly map onto these stages, although changes are nonlinear over time.10 In the early menopausal transition, follicle-stimulating hormone (FSH) levels (measured in the early follicular phase of the menstrual cycle) are elevated but variable. The majority (80%) of cycles are still ovulatory,11,12 and thus, menstrual cycle-related hormone changes are superimposed on menopausal transition changes; within any ovulatory menstrual cycle, follicular phase estradiol (E2) levels tend to be lower, luteal phase E2 levels tend to be higher, and luteal phase progesterone levels are lower than in reproductive-aged women.13 The late menopausal transition is characterized by FSH levels ≥25 IU/L.9 Early postmenopause (first 1–6 years after final menses) is characterized by a continued rise in FSH levels and decline in E2 levels particularly over the first 2 years after the final menstrual period,9 after which FSH levels gradually stabilize. Perimenopause is a term commonly used, especially before STRAW criteria were developed, to describe the menopausal transition and first-year postmenopause, and lasts a median of 4 years.14 HFs (or flushes) – a common symptom of impending menopause – typically emerge in the late reproductive stage or early menopausal transition, peak in the late menopausal transition and first 2 years after menopause, and decline in late menopause (>6 years after final menstrual period).15 Studies have also used the term “vasomotor symptoms” to describe HFs and night sweats.
In women with amenorrhea or unreliable bleeding patterns, such as endometrial ablation, hysterectomy, treatment of malignancy, and chronic illness, endocrine markers of ovarian aging, such as a rise in FSH, are required to identify the timing of the menopausal transition.15 Women who have bilateral oophorectomy (removal of ovaries) are plunged into menopause, with a rise in FSH and drop in estradiol, and sudden appearance of menopausal symptoms, which are typically more severe than with natural menopause.16 Women with hysterectomy alone (ovaries are intact) and hysterectomy plus oophorectomy may be combined into a single category, “surgical menopause”, although it should be kept in mind that the endocrine environment differs between these two groups.
Sleep difficulties reported across the menopausal transition
Midlife women transitioning menopause and postmenopause are more likely to report sleep difficulties, with prevalence rates of self-report sleep difficulties ranging between 40% and 56%, compared to premenopausal women in the late-reproductive stage, who have rates of 31%.17 This greater prevalence of sleep difficulties in association with the menopausal transition, even after controlling for age, is evident across many cross-sectional studies from different countries despite wide variability in the assessment and definition of sleep difficulties and menopausal staging, and the number of covariates controlled, as shown in a recent meta-analysis of cross-sectional data from 24 studies.18 Women in perimenopause (1.60), postmenopause (1.67), and surgical menopause (2.17) had higher odds of experiencing sleep disturbance, relative to premenopause.18
Longitudinal studies are well suited to examine the change over time in sleep difficulties as women progress through the menopausal stages as well as in relation to hormone changes. Such studies have mostly confirmed cross-sectional data and revealed some nuances in the relationship between menopause and sleep difficulties.19–25 Longitudinal analysis of 8 years of data from >3000 women in the Study of Women’s Health Across the Nation (SWAN) showed that sleep difficulties due to frequent awakenings (over the past 2 weeks), in particular, increased as women transitioned menopause and was the most common problem (Figure 2).22 Some differences related to ethnicity emerged, with Caucasian women showing the greatest odds and Hispanic women showing the lowest odds of frequent awakenings, although ethnicity–menopausal stage interaction effects were negligible.22 In their longitudinal analysis, Tom et al24 showed the importance of considering severity of sleep difficulties, with a stronger relationship between menopausal stage and bothersome trouble sleeping (over the past year) for those women with severe vs moderate sleep difficulties. Both of these studies confirmed cross-sectional data that women who transitioned to surgical menopause and were not taking hormone therapy (HT) had the greatest odds of sleep difficulty (Box 1).22,24 The Penn Ovarian Aging Study did not observe a relationship between menopausal status or age with sleep quality assessed for previous night23 or any difference in the prevalence of “trouble sleeping over the past month” relative to the final menstrual period in the sample overall,21 although there was a strong association between vasomotor symptoms and poor sleep regardless of stage.21,23 An important finding from this study was that premenopausal sleep status was the strongest predictor of poor sleep around the final menstrual period, supporting other work that a history of insomnia is a strong predictor of current symptoms.32
Figure 2 Age-adjusted odds ratios for self-reported sleep difficulties in women participating in the SWAN prospectively tracked across the natural menopausal transition relative to premenopausal baseline and in women who transitioned to surgical menopause.
Notes: *P<0.05; **P<0.01; ***P<0.001. Data from Kravitz et al.22
Abbreviation: SWAN, Study of Women’s Health Across the Nation.
Box 1 The impact of surgical menopause or treatment of malignancy on sleep quality
Some studies have considered relationships between hormone levels (as opposed to only bleeding patterns) and sleep difficulties. In the Seattle Midlife Women’s Health Study cohort, higher FSH and lower estrone levels were associated with greater severity of nighttime awakenings; however, this relationship did not remain significant in multivariate analysis.25 In a cross-sectional study of 160 peri- and postmenopausal women, no relationship was found between E2 or FSH with diary-reported sleep measures, although wake time was strongly associated with menopausal stage.33 Longitudinal studies are better suited for tracking changes in hormone levels in relation to changes in sleep: SWAN found that decreasing E2 and increasing FSH levels were associated with higher odds of frequent awakenings across follow-ups22 and that a greater rate of change in FSH was associated with poorer sleep quality.34 Also, the 13-year prospective Melbourne Women’s Midlife Health Project found that a steeper E2 slope was associated with more severe sleep problems,10 and some evidence suggests that declining estradiol levels are associated with worsening sleep quality even in late reproductive stage women.35
Together with evidence of worsening sleep quality following oophorectomy, when the change in hormones is sudden, these results imply that a faster change in hormones is associated with a poorer sleep profile. In summary, there is an increase in the prevalence of sleep difficulties as women traverse menopause, evident in relation to menopause stages based on bleeding patterns as well as endocrine changes. Sleep problems are multifactorial, strongly associated with HFs and depression (as discussed later), as well as other factors coincident with aging into midlife including stress, poor health and chronic pain.25,36,37 There is also an age-related increase in the presence of sleep-related breathing and movement disorders, as discussed later. These factors may also interact with each other, providing a complex basis for sleep difficulties in midlife women. As such, investigations of subgroups of women38 and consideration of clusters of symptoms in women rather than just focusing on the menopausal transition25 may be valuable approaches. Limited data also suggest that differences in circadian regulation (advanced circadian phase) could contribute to sleep difficulties,39 particularly a more fragmented sleep or early morning awakening, in postmenopausal women. Finally, an additional source of variability to hormone levels and sleep quality when women are in the early menopausal transition is menstrual cycle phase; women have a poorer sleep quality in the late-luteal and early-follicular phases than at other times.40,41
Polysomnographic measures in women in the menopausal transition
Epidemiological studies clearly show a rise in self-reported sleep difficulties as women transition menopause. These data reflect how women are feeling, which is highly relevant to their use of health care and quality of life.22 Polysomnography (PSG), including electroencephalographic (EEG) analysis, provides detailed information about biological sleep and its regulation, and is also a powerful tool for examining relationships between aspects of sleep and other biological measures, such as hormone levels and cardiovascular and respiratory functions. Importantly, while not required for an insomnia diagnosis, PSG (or a reduced subset of these signals) is essential for diagnosing sleep disorders such as obstructive sleep apnea syndrome. However, PSG-derived measures of sleep do not necessarily reflect self-report sleep quality ratings.42
Given the multiple factors evident from epidemiological studies that can influence sleep difficulties and their measurement across the menopausal transition (eg, presence of preexisting sleep complaints, severity of sleep complaints, symptoms such as HFs, variable hormone fluctuations, and the influence of other conditions coincident with midlife), it perhaps is not surprising that PSG studies have not consistently shown evidence of sleep disturbances linked directly with menopausal stages (Table 1). Most PSG studies have been observational and conducted in smaller, select samples, on one or only a few nights, which capture a snapshot of sleep. Furthermore, most studies did not control for confounding factors such as age, health status, medications, and presence of a sleep disorder. Two large cohort studies designed to address some of these limitations are the Wisconsin Sleep Cohort and SWAN studies. The Wisconsin Sleep Cohort Study of 589 midlife women showed that peri- and postmenopausal women had better PSG sleep, with more slow wave sleep (SWS), than premenopausal women,43 whereas SWAN found no differences in PSG measures according to menopausal status.44 However, late-perimenopausal stage and postmenopausal women had more high-frequency beta EEG activity, suggesting greater cortical hyperarousal, during sleep than premenopausal and early-perimenopausal stage women, an effect partially explained by higher frequency of self-report HFs.44 Taken together, studies have shown few consistent effects of menopausal stage per se on sleep architecture. Results of SWAN, however, show the potential relevance of considering more complex measures of sleep quality, such as quantitative EEG. Also, taken together, results suggest that while not all women experience sleep disruption in association with the menopausal transition, subgroups might be more susceptible, such as those with severe HFs and/or insomnia disorder. Most importantly, PSG studies have been cross-sectional except for one45 and, therefore, are unable to track the trajectories of change in PSG measures in relation to transitioning menopause. Women may begin to experience menopausal symptoms even in the early 40s, when they are still premenopausal, which could confound cross-sectional comparisons between different stages.
Lampio et al45 used a longitudinal design to investigate the changes in PSG measures in 60 midlife women six years after a premenopausal baseline visit. At follow-up, women had a shorter total sleep time, lower sleep efficiency, more wakefulness after sleep onset (WASO), and more awakenings after adjusting for HFs/night sweats, body mass index, and mood, an effect linked with advancing age rather than increased FSH levels. In contrast, increasing FSH was associated with an increased proportion of SWS (although not with slow-wave EEG activity), which the authors propose as reflecting an adaptive change to counteract the age-related sleep fragmentation.45 SWAN data also found a link between the change in FSH over time and more SWS as well as a longer total sleep time,34 which contrasts with findings correlating hormone changes with subjective sleep quality as described earlier. The relationship between reproductive hormones and sleep appears to differ in the reproductive years and earlier in the menopausal transition: in a cross-sectional study of young premenopausal and early menopausal transition women, all in the follicular phase, we found a correlational relationship between higher FSH levels and more WASO but not with other sleep measures, as assessed with single-night, in-laboratory PSG,46 suggesting an interaction between hormones of the hypothalamic pituitary ovarian axis and sleep–wake regulatory systems that is apparent even in reproductive-age women. These data are correlational, however, and further studies tracking frequent changes in hormone levels in association with sleep are needed. There is growing evidence, from animal models, of the underlying mechanisms of how reproductive hormones act to alter sleep and circadian rhythms, although many knowledge gaps remain and the mechanisms are likely complex.47
Interestingly, when we looked separately at women with insomnia disorder developed in the context of the menopausal transition, they did not show any FSH–WASO relationship, possibly due to the influence on their sleep of other factors such as mood, hyperarousal, and night-to-night variability.46 These data further indicate the challenge in isolating the influence of hormones from the several other confounding factors that affect sleep.
HFs and reported sleep difficulties
HFs are a hallmark of the menopausal transition, being reported by up to 80% of women.48–51 A HF is a sensation of heat, sweating, flashing, anxiety, and chills lasting between 3 and 10 min52 and is primarily a thermoregulatory phenomenon53 with characteristics of a heat dissipation response: peripheral vasodilation, which causes increased heat loss, and increased sweating, which causes evaporative cooling. Some women have HFs hourly or daily, and others report only 1 or 2/week.52 HFs can occur during the day or night (night sweats).52 Data from SWAN show that the median duration of HFs is 7.4 years.48 The temporal pattern of HFs across the menopausal transition is not the same for all women, with studies identifying distinct patterns based on the time of symptom onset and persistence.51,54,55 The SWAN study showed that these different trajectories are associated with health, with women in the “persistently high/early onset” group having a more adverse health and psychosocial profile.51 Also, early-onset HFs are associated with greater subclinical cardiovascular disease.56
HFs emerge as estrogen levels decline, but their mechanism is more complex than just estrogen withdrawal, with several lines of evidence implicating the involvement of central noradrenergic activity57–59 as well as serotonergic mechanisms,57 and most recently, involvement of hypothalamic kisspeptin, neurokinin B, and dynorphin (KNDy) neurons.60 Since not all women develop HFs (despite showing the expected decline in estradiol going through menopause) and since severity, frequency, and duration vary among women, neural systems may be altered in vulnerable women, leading them to be more sensitive to the effects of estrogen fluctuations.
The presence of self-reported HFs is consistently associated with poorer self-reported sleep quality and chronic insomnia17,22,37,41,61 indicating that women link HFs with nocturnal awakenings. Longitudinal data from SWAN show that women with moderate-to-severe HFs (6–14 days in a 2-week period) are almost three times more likely to report problems of frequent nocturnal awakenings compared to women without HFs.62 HF-associated bother and interference over and above frequency appear to be important constructs to consider; Xu et al63 reported that bothersome HF but not HF alone was associated with sleep difficulties. Further supporting HFs as a cause of poor sleep are studies showing that the effective treatment of HFs with HT is associated with improved sleep quality.2,4,64 Recently, Pinkerton et al65 analyzed clinical trial data in women with frequent moderate-to-severe HFs (≥7/day) and quantified the effect on quality of life and sleep problems of reducing the number and severity of HFs with treatment; a reduction of five HFs per day is associated with a clinically meaningful reduction in sleep problems. Critically, HFs can emerge in the late 30s and 40s, and are associated with poor sleep even at this late-reproductive stage.35 Given that HFs can continue to persist for several years postmenopause in some women, they may be an important source of sleep disturbance well after midlife.66
Polysomnographic measures in women with HFs
As for PSG studies comparing sleep in women at different menopausal stages, PSG studies comparing sleep in women with and without HFs have produced results inconsistent with self-reported evidence of a strong link between HFs and sleep difficulties (Table 1). Some of these inconsistencies are related to methodological issues of studying sleep in the menopausal transition, as described earlier, and additional methodological challenges associated with HFs. HFs have been assessed based on self-report over a previous averaged time period of days or weeks or during the recording night (with self-report measures differing in the assessment of frequency, severity, and bother), or assessed based on the “objective” measures of sternal skin conductance. An HF is objectively identified by a sudden increase in sternal skin conductivity due to a sweat response, which tails off as sweating decreases, considered the gold standard method of measuring HF frequency.67 Concordance between self-report and objective HFs varies widely between studies and is particularly low due to under reports when an HF occurs at night,67 not surprising since retrospective recall of nighttime HF events on the following morning may be inaccurate and confounded by fatigue and mood64,68 as well as being dependent on having woken up at the time of the HF to remember the event. Finally, most studies have been observational rather than using interventions, limited in determining causality between HFs and disturbed sleep. Although self-report HF may be biased by the “retrospective” nature of the morning self-report, it is still clear that women recall the presence of HFs at night only when they are associated with a conscious awakening, and thus, each self-reported HF is truly associated with nocturnal wakefulness, a factor that should increase the strength of the subjective HF–sleep association. In contrast, not all the objectively recorded HFs are associated with awakenings,69 a factor that seems to affect the relationship between objective HFs and sleep disruption.
Self-report HFs have been associated with EEG hyperarousal during sleep in the SWAN study,44 whereas others showed no differences in PSG markers of sleep disturbance,43,70,71 or more time in bed72 or longer sleep time73 between women reporting HFs vs women not reporting HFs. Similarly, for objectively measured HFs, symptomatic postmenopausal women compared with asymptomatic postmenopausal women had a poorer PSG-defined sleep profile (more awakenings and lower sleep efficiency) in one study74 or no difference in PSG measures in another study.76 To further explore the relationship between HF and PSG-measured sleep, we and others have conducted more refined analysis on individual HF events and PSG measures in women with HFs in the menopausal transition or postmenopause.69,75–78 Studies are consistent in showing a low incidence of HFs in REM sleep,69,76,77 possibly owing to the inhibition of thermoregulatory responses in this stage. However, studies are not consistent in showing HF–wake associations, with reports of awakenings more likely to occur before an HF than after an HF,76 HFs occurring before an awakening only in the first half of the night,77 or HFs coincident with awakenings in the majority of events,69,75,78 with no differences in the first and second parts of the night.69 We found that ~80% of HFs in our sample interfered with sleep.69 Differences between studies might relate to how HFs were classified as associated and not associated with awakenings and how the windows of analysis were defined,69 as well as variability between women in the extent to which HFs disrupt sleep.
Emerging data have shown the importance of using experimental manipulations and looking beyond HF frequency to explore relationships between sleep and HFs: in a controlled model of new-onset HFs, HFs were linked with more PSG awakenings, more WASO, and more light Stage N1 sleep in young premenopausal women treated with a gonadotropin-releasing hormone (GnRH) agonist that simulates menopause;79 WASO time increased, on average, by 6.3 min for each additional HF measured. Furthermore, the majority (66%) of HFs occurred during wake or Stage N1 sleep (few HFs occurred during REM sleep), with no difference in the first and second halves of the night.80 We recently developed an index to determine how much wake time was associated with HFs rather than only considering HF frequency: in a group of women in the menopausal transition with mild-to-moderate HFs, HF-associated wake time was responsible for, on average, 27% of objective WASO, although with wide variability in HF impact between women (Figure 3).69 This index correlated with self-reported estimates of wakefulness, showing that women are attuned to awakenings associated with HFs.69
Figure 3 Amount of PSG-defined wakefulness associated with hot flashes relative to total WASO in individual women who presented with varying numbers of hot flashes, as measured from sternal skin conductance, during overnight laboratory stays.
Notes: There was high variability between women in the number of hot flashes measured and in their associated amount of wakefulness. Data from de Zambotti et al.69
Abbreviations: PSG, polysomnography; WASO, wakefulness after sleep onset.
In summary, while not all HFs are associated with disturbed sleep and not all wakefulness is associated with HFs, HFs are a strong correlate of poor sleep and many HF events are closely linked with periods of wake measured with PSG. The strong overlap in timing between HF onset and awakenings that we and others have found suggests that these events may be driven by a common mechanism within the CNS in response to fluctuating estrogen levels, although sweating triggered by an HF may still contribute to or extend the interval of waking.69 Freedman and colleagues have conducted several studies exploring the mechanism of the HF and hypothesize that declining estradiol levels trigger HFs mediated by central sympathetic nervous system activation.81 This group also showed, using fMRI, that there was a greater activation in the anterior insular cortex during the 20s period immediately before a rise in skin conductance (marking HF onset) compared with the first 20s of the HF, suggesting that it plays a role in the mechanism of an HF.82 How this activation pattern might also relate to an awakening coincident with a HF is not clear but does indicate the relevance of looking at changes in EEG and other physiological measures in advance of the skin conductance rise marking an HF. Nocturnal HFs are an important component of sleep disturbance during midlife, particularly in women with severe sleep difficulties, that qualifies them for insomnia disorder, as discussed later.
Impact of sleep difficulties in the menopausal transition
Severity and duration of sleep difficulties vary in women transitioning menopause, with some having occasional poor nights of sleep, which are bothersome and transiently impact quality of life. Others have chronic and severe sleep difficulties, associated with greater and more prolonged impact on daytime functioning, quality of life, and health. Insomnia disorder in the general population is linked with adverse mental and physical conditions,83 including depression and cardiovascular disease,84 and insomnia combined with short sleep duration is proposed as the most biologically severe phenotype of the disorder.85 Furthermore, longitudinal data from a population of community-dwelling postmenopausal women specifically linked insomnia with increased vulnerability to physical and mental impairments.86 It is unclear if severe sleep difficulties that either develop or are exacerbated, in the context of the menopausal transition, have a similar impact or different impacts on long-term health compared with insomnia developed at other times, and how comorbid features such as the presence of severe HFs, depression, and poor physical health might interact with sleep difficulties to contribute to impairment.
Data are emerging from longitudinal studies such as SWAN linking midlife sleep problems with subsequent mental health: women with sleep problems, in late reproductive stage or early in the menopausal transition, are at greater risk for persistent/recurrent depression relative to single episode major depressive disorder (MDD), over and above risk conferred from having a lifetime history of depression.87 Recent cross-sectional data also link poor sleep with subclinical cardiovascular risk markers.88,89 Poor subjective sleep quality and short sleep duration (from actigraphy) were associated with increased carotid atherosclerosis in peri/postmenopausal women, independent of HFs.88 Longitudinal data from SWAN found that lower sleep efficiency was related to increases in resting systolic and diastolic blood pressures and increased risk for incident hypertension across follow-up and lower NREM delta power was associated with greater increase in diastolic blood pressure over time, after adjustment for age and baseline blood pressure.90 However, after adjustment for additional factors (including race, BMI, and diabetes mellitus), associations were no longer significant, apart from that between delta power and diastolic blood pressure. We have focused our studies on women with clinically significant sleep complaints (insomnia) developed in the context of the menopausal transition and found that these women have altered autonomic and cardiovascular regulation, including a less-sustained dip in blood pressure across the night relative to women without insomnia.91 A less effective “cardiovascular holiday” during the night may have consequences for long-term cardiovascular health, which needs to be investigated in the context of menopausal insomnia in future work.
Sleep and mood disturbance in the menopausal transition
The bidirectional relationship between sleep and mood disturbances is well established across genders and ages. Up to 90% individuals with MDD have sleep complaints,92 and MDD has also been associated with alterations in objectively measured sleep.93 In nonpsychiatric populations, self-reported poor sleep has been consistently associated with symptoms of depression and anxiety,94,95 while the association between objectively measured sleep duration/quality and mood symptoms is comparably weaker.96
Several longitudinal studies have found that depressive symptoms increase during the menopausal transition.97 The associations between sleep and mood disturbances in women going through the menopausal transition are largely consistent with those reported in the general population. Cross-sectional studies with self-report sleep measures have found consistent and strong associations between poor self-report sleep or greater symptoms of insomnia, with higher symptoms of depression33,61,98–105 and anxiety.61,99,101,103,106 These include large-scale epidemiological studies, those that included women of both Caucasian and non-Caucasian background, and those in premenopausal, menopausal transition, and postmenopausal stages. One study further suggested that sleep initiation problems may be associated with anxiety, while nonrestorative sleep may be associated with depression.103
Findings are somewhat less consistent when sleep is measured via objective methods but point to an association between objective sleep disturbance and worse mood. In women with HFs aged >40 years, those with depression had shorter sleep duration, longer sleep onset latency, and lower SE (but not number of awakenings or WASO) based on actigraphy compared to those without depression.107 In healthy samples, poorer actigraphy-measured sleep was associated with worse mood in menopausal but not in premenopausal women.108 In a study of pre-, peri-, and postmenopausal women with subclinical depressive symptoms, Toffol et al found that higher depression scores on the Beck Depression Inventory were associated with lower sleep efficiency and shorter total sleep time in perimenopausal women and with more REM sleep in postmenopausal women, after controlling for age, although effects were lost when sleep-related items of the questionnaire were removed.109
Longitudinal studies are rare. One study followed 309 women aged 43–53 years for 5 years and found that depressive symptoms were not related to menopausal status or annual change in estradiol but were associated with HFs and sleep disturbance.110 A 13-year longitudinal study on 297 premenopausal women aged 42–52 years from SWAN found that those who experienced persistent/recurrent MDD during annual follow-ups were more likely to have reported sleep problems at baseline.87 Therefore, sleep problems during the menopausal transition are not only associated with concurrent symptoms of depression and anxiety but may also be a risk factor for depression in the future.
Mechanisms for the sleep–mood association are not well understood. It is possible that mood disturbances may result from poor sleep via neurobiological111 as well as psychological112 mechanisms. For example, in perimenopausal women, unhelpful thoughts and beliefs about sleep were found to mediate the relationship between poor sleep and mood disturbances.101 It is also possible that sleep and mood disturbances are linked via common causes that exert simultaneous influence on both processes. Another potential common cause is age-related changes in circadian regulation. Circadian processes are critical to sleep/wake regulation and play a role in mood and affect.113 Consistent with findings in general populations, later circadian phase markers were linked to both higher anxiety114 and the presence of depression115 in menopausal women.
HFs have also been examined as a potential link with mood disturbances, with some theorizing that HFs disrupt sleep, which in turn leads to daytime mood symptoms (domino effect)116 or via bothersomeness of HFs.117 However, not all women with HFs develop depression and many midlife women experience depression in the absence of HFs.118 More recently, investigators have shown some differentiation between HF–sleep and depression–sleep relationships, at least in postmenopausal women. HFs and depression had an additive effect on self-report sleep disturbance,105 and self-report HFs and depression symptoms were associated with different sleep disturbance patterns, with HFs being uniquely associated with frequent awakenings, whereas depression was uniquely associated with difficulty falling asleep and waking up earlier than desired119 in a clinical sample of postmenopausal women. Results from a clinical trial further show independence of HFs, mood, and sleep: Joffe et al120 found that increasing estradiol (in perimenopausal women) and improved sleep quality (in peri/postmenopausal women) predicted improved mood, but reduced HFs did not. To further investigate the interdependency between sleep, HFs, and mood, Joffe et al121 conducted an experimental study that induced HFs in healthy nonmenopausal women. They found that PSG-measured sleep and nighttime HFs independently predicted mood deterioration.
It is worth noting that although sleep disturbance is a significant concern during the menopausal transition and longitudinal changes in menopausal status over time are associated with increased risk of depressive symptoms, the rate of MDD as a psychiatric disorder is similar to that at other times in a woman’s reproductive life.122 Therefore, proactively treating clinically significant mood disorders, normalizing some degree of mood disturbances, and effectively addressing sleep problems may benefit psychological well-being during the menopausal transition.
Sleep disorders in the context of the menopausal transition
Sleep-disordered breathing (SDB)
Women have an increased risk of SDB after menopause, attributed to aging and menopause-related factors,123–125 as reviewed in detail elsewhere.2,126,127 In fact, Freedman and Roehrs128 found, in a sample of midlife women with sleep complaints, that 53% had SDB, periodic limb movement disorder, or both and that the apnea–hypopnea index (AHI), periodic limb movement index, and arousals, but not HFs, were predictors of PSG-defined SE. The community-based SWAN study found 20% prevalence of moderate/severe SDB (>15 apnea + hypopnea events/hour) in midlife women,129 substantially higher than reports for younger, premenopausal women (4%).130
Progression through menopausal stages is associated with SDB severity, with a 4% higher AHI for every additional year since entering the menopausal transition, independent of age, BMI, and neck and waist circumferences, although these factors were also associated with a higher AHI.131 The decline in estrogen and progesterone after menopause likely plays a role in increased risk for SDB; progesterone increases ventilatory drive and affects upper airway dilatory muscles132 and partly mediates its effects through estrogen-dependent receptors;133 hence, the menopausal decline in both these hormones could impact respiration. Also, HT is associated with a lower prevalence of SDB,123,125 although clinical trials of HT have produced conflicting results.134 A change in body habitus, with increased weight gain and an accumulation of adipose tissue in the upper part of the body as well as a shift toward visceral adipose deposition as women progress through the menopausal transition, is also a critical risk factor for SDB after menopause.125,131
Given the health risks associated with untreated SDB, women suspected of having the disorder should be formally evaluated and treated; continuous positive airway pressure (CPAP) remains the treatment of choice for SDB in peri- and postmenopausal women.
Epidemiological studies have varied in their assessment of the presence and severity of sleep difficulties, and while there is a clear increase in poor sleep quality as women transition menopause, it is important to distinguish who experiences severe and persistent sleep disturbance associated with daytime impairment, qualifying them for insomnia disorder (Table 2). Based on a phone interview of 982 women, Ohayon37 reported that 26% of perimenopausal women qualified for a DSM-IV diagnosis of insomnia (with insomnia duration set at 6 months rather than 1 month), with difficulty maintaining sleep being the most common symptom. Some women had preexisting insomnia symptoms before entering the menopausal transition, but one-third (31.8%) reported that their insomnia symptoms were related to the development of menopause.37
A major factor in the increased prevalence of insomnia disorder in midlife women was HFs; experiencing HFs (mild, moderate, or severe) was strongly associated with a diagnosis of insomnia, with the likelihood of having chronic insomnia symptoms increasing with the severity of HFs.37 Similarly, HF severity was a significant factor associated with high insomnia severity index scores in midlife women.136 Some women may be more vulnerable to the development of insomnia disorder in the context of the menopausal transition; we found that women with first-onset insomnia disorder relative to controls, all in the menopausal transition, were more likely to have obsessive–compulsive personality disorder, a past depressive episode, and a history of severe premenstrual symptoms.137 Also, higher neuroticism (the general tendency to experience negative affect such as fear, sadness, anxiety, embarrassment, anger, and guilt) along with greater interference from HFs (eg, with work and social activities), was associated with insomnia classification.137 As shown with prospective SWAN data, chronic stress exposure also predisposes midlife women to insomnia.138 In the context of the menopausal transition, therefore, classical clinical features of insomnia such as elevated rumination, anxiety, generalized hyperarousal, stress reactivity, and neuroticism139–141 seem to overlap with aspects of insomnia specific to the menopausal transition, such as HFs.
While studies have not linked gross disturbances in PSG-derived sleep measures with menopausal stages in population studies of midlife women (despite subjective sleep difficulties), we found stark differences in PSG measures in women with, relative to women without, insomnia disorder developed in the menopausal transition.142 Women meeting DSM-IV criteria for insomnia had a poorer SE, more WASO, and shorter TST, with almost 50% of them having <6 hours of TST during a laboratory PSG study. Importantly, women with insomnia were more likely to have objective HFs and the presence of HFs predicted the number of PSG-awakenings per hour of sleep,142 supporting the critical role of HFs in insomnia in the menopausal transition context.37 Based on sleep diaries, women with insomnia also reported a shorter TST, with more awakenings and more HFs compared to women without insomnia.142 In an interesting comparison of peri/postmenopausal and premenopausal women with insomnia (all aged between 40 and 59 years), Xu et al143 found that subjective measures, including scores on the insomnia severity index, Beck depression inventory, and sleep diary measures, were similar between the two groups but that peri/postmenopausal women with insomnia had a longer PSG-defined total wake time and lower SE (81.8% vs 86.0%). While this study has some limitations since the presence of HFs was not considered and insomnia did not necessarily develop in the menopausal transition, results suggest that PSG measures of sleep quality are impacted to a greater extent in peri/postmenopausal than in premenopausal women with insomnia.
Chronic stress could add a layer of complexity to PSG sleep disturbance in insomnia disorder in midlife women – Hall et al138 found that women with more chronic stress exposure over a 9-year period had greater PSG-assessed WASO (as well as being more likely to have insomnia) than participants with moderate stress exposure. We also found that women with insomnia showed less within-night recovery in autonomic vagal functioning following pre-sleep acute stress exposure144 as well as raised HR145 and raised blood pressure91 during sleep relative to women without insomnia, also in the menopausal transition.
Taken together, PSG studies focused on women with insomnia disorder in the menopausal transition show evidence of disrupted sleep, partly in association with HFs, as well as less efficient autonomic and cardiovascular recovery during sleep compared to women without insomnia disorder. No matter what the precipitating factors for insomnia are, behavioral conditioning and sleep-associated behaviors may prolong insomnia;127 these behaviors need to be addressed in order to successfully treat insomnia.
Management of insomnia in the menopausal transition
Insomnia in the context of the menopausal transition may be attributed to multiple overlapping factors, making treatment challenging and requiring a flexible and individualized response. Assessment procedures and treatment options for insomnia in the context of the menopausal transition are provided in Figure 4. In some cases, combined treatments may be required, such as for women who have severe HFs, sleep problems, and depression. Options include HT, nonhormonal pharmacological medications, and behavioral interventions. Randomized clinical trials have shown that successful treatment of severe HFs with HT, and more recently, with selective serotonin/serotonin norepinephrine reuptake inhibitors, also leads to improvements in sleep quality, although the side effect profiles of these medications need to be carefully considered before use.2,146,147 Dietary supplements for menopausal symptoms have also been investigated. Soy isoflavones, for example, have been shown in randomized controlled trials to reduce menopausal symptoms148, including self-reported sleep disturbance.149,150
Figure 4 Assessment and management of insomnia in the context of the menopausal transition. Importantly, chronic sleep maintenance insomnia in women with menopausal symptoms is associated with a negative impact on healthcare utilization, quality of life, and work productivity.173
Abbreviations: CBT-I, cognitive behavioral treatment of insomnia; HF, hot flash; HT, hormone therapy.
Cognitive behavioral treatment of insomnia (CBT-I), considered the primary intervention for all patients with chronic insomnia,151 should be similarly considered for women with insomnia in the menopausal transition. CBT-I typically includes sleep hygiene to improve sleep conditions, sleep restriction to increase sleep efficiency, stimulus control focused to enhance the association between bed and sleep, and cognitive restructuring to reduce dysfunctional beliefs and attitudes about sleep. In nonmenopausal populations, CBT-I approaches consistently improve sleep,152 including when sleep disturbance and insomnia are comorbid with other mental and physical health conditions.153 Compared to sleep medication alone, effects of CBT-I are comparable in the short term and superior in the long term.154 However, CBT-I has only recently been evaluated specifically for insomnia during the menopausal transition. McCurry et al155 conducted a randomized clinical trial on 106 peri- and postmenopausal women with insomnia symptoms and ≥2 HFs daily, comparing 8-week telephone-administered CBT-I with menopause education as control. Compared to the control condition, the CBT-I condition had significantly greater reduction in insomnia symptoms and greater improvements in self-report sleep quality; these improvements were maintained at 6 months posttreatment and were clinically meaningful.155 Interestingly, there were no group differences in ratings of HF frequency (day or night), severity, or bother, although HF-related interference was reduced, mostly due to a reduction in sleep-related interference from HFs,155 suggesting that women may still have woken up in association with HFs but were able to return to sleep faster in the treatment group. Preliminary data from an open trial of CBT-I in women whose sleep was affected by menopause also indicated a significant reduction in insomnia (and depression) symptoms posttreatment.127 These promising findings provide empirical evidence for future implementation and dissemination of CBT-I in menopausal populations.
A factor that has not yet been addressed for insomnia in the context of the menopausal transition is whether interventions may be applied in advance of menopausal symptoms to protect against insomnia. In the context of insomnia in general, it has been suggested that it would be beneficial to identify individuals vulnerable to insomnia and provide primary prevention (eg, education on stress management) and secondary prevention (eg, modify sleep-related behaviors) to prevent relapse or maintenance of insomnia.156 Similarly, women vulnerable to insomnia in the context of the menopausal transition (eg, history of severe premenstrual syndrome and neurotic personality style137) may benefit from preventative interventions. Also, certain behaviors may protect against sleep problems; high levels of recreational physical activity are associated with better sleep in midlife women.157
Sleep difficulties increase in prevalence as women transition menopause. For some women, sleep problems are severe and impact daytime functioning and quality of life and may have long-term consequences for mental and physical health. Further research is needed to better understand factors that contribute to the development of sleep disturbance in the context of the menopausal transition, as described in Box 2. HFs are a unique aspect of insomnia in the menopausal transition and are strongly associated with reports of disrupted sleep, and HF-associated wakefulness makes a significant contribution to the amount of PSG-measured wakefulness during the night. In addition, given the co-occurrence of HFs and awakenings, women attribute those awakenings as specifically caused by HFs. Since some women may have sleep problems independent of HFs, other factors directly related to the menopausal transition (eg, instability/changes in the hormone environment with progressive decreases in estradiol and increases in FSH) and/or coincident with the transition (eg, SDB or movement disorders, mood disturbance, presence of a medical condition, and life stressors) also need to be considered. It, therefore, is critical to assess insomnia symptoms in the context of menopause as well as considering physical and mental health and presence of stressful life events. Given the presence of unique sleep-disruptive factors (eg, HFs) and the multifactorial nature of sleep difficulties in women approaching menopause, with multiple factors often interacting, treatment needs to be tailored for women.
Box 2 Research agenda
This study is supported by the National Institutes of Health, Grant HL103688 (FCB). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
The authors report no conflicts of interest in this work.
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