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Sitagliptin Increases Beta-Cell Function and Decreases Insulin Resistance in Newly Diagnosed Vietnamese Patients with Type 2 Diabetes Mellitus

Authors Le TD, Nguyen NTP, Nguyen ST, Tran HTT, Nguyen LTH, Duong HH, Nguyen HM, Do BN

Received 23 March 2020

Accepted for publication 29 May 2020

Published 19 June 2020 Volume 2020:13 Pages 2119—2127

DOI https://doi.org/10.2147/DMSO.S255071

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Muthuswamy Balasubramanyam


Tuan Dinh Le,1,* Nga Thi Phi Nguyen,2,3,* Son Tien Nguyen,2,3 Hoa Thi Thanh Tran,4 Lan Thi Ho Nguyen,4 Hoang Huy Duong ,1 Ha Manh Nguyen ,4 Binh Nhu Do5,*

1Department of Internal Medicine, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam; 2Department of Endocrinology, Military Hospital 103, Ha Noi, Vietnam; 3Department of Rheumatology and Endocrinology, Vietnam Military Medical University, Ha Noi, Vietnam; 4The National Endocrinology Hospital, Ha Noi, Vietnam; 5Division of Military Science, Military Hospital 103, Ha Noi, Vietnam

*These authors contributed equally to this work

Correspondence: Nga Thi Phi Nguyen; Binh Nhu Do Email ngabv103@yahoo.com.vn; nhubinh.do@vmmu.edu.vn

Introduction: To investigate effects of Sitagliptin on the enhancement of beta-cell function, reducing insulin resistance, serum glucagon like peptide-1 (GLP-1) concentrations and blood glucose in patients with type 2 diabetes mellitus (T2D) and suggest one of the underlying mechanisms on beta-cell function and insulin resistance.
Patients and Methods: This was a cross-sectional and observational study in comparison to the control group. A study population of 44 newly diagnosed patients with T2D treated with Sitagliptin with a dose of 100 mg/day for 3 months was analyzed to compare 52 healthy participants. Indices for beta-cell function, peripheral insulin sensitivity, and insulin resistance were calculated with homeostasis model assessment 2 (HOMA2) calculator and compared. Serum GLP-1 concentrations were analyzed, and regression analysis was conducted to find the correlations between GLP-1 and beta-cell function and insulin resistance.
Results: Newly diagnosed patients with T2D witnessed a significant reduction in beta-cell function, serum GLP-1 concentrations at the time of diagnosis. After treatment with Sitagliptin 100 mg/day, they achieved significant improvements in beta-cell function, peripheral insulin sensitivity and insulin resistance. Serum GLP-1 concentrations were increased significantly to those levels in the control group and correlated with peripheral insulin sensitivity and insulin resistance in patients whose beta-cell functions improved.
Conclusion: Sitagliptin improved beta-cell function, insulin resistance and blood glucose in newly diagnosed patients with T2D. Meanwhile, Sitagliptin ameliorated serum GLP-1 concentrations, which contributed to the enhancement of beta-cell.

Keywords: Sitagliptin, serum GLP-1 concentrations, beta-cell function, insulin resistance, newly diagnosed patients with type 2 diabetes mellitus

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