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Significant association of BDNF rs6265 G>A polymorphism with susceptibility to epilepsy: a meta-analysis

Authors Xu Y, Li X, Zhuang S, Guo S, Xiang J, Wang L, Zhou L, Wu B

Received 23 October 2017

Accepted for publication 5 February 2018

Published 16 April 2018 Volume 2018:14 Pages 1035—1046

DOI https://doi.org/10.2147/NDT.S154927

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 3

Editor who approved publication: Professor Wai Kwong Tang


Yue-Long Xu,1,* Xiu-Xiu Li,1,* Su-Jing Zhuang,1 Shi-Feng Guo,1 Jian-Ping Xiang,1 Long Wang,2 Lan Zhou,2 Bin Wu3

1Department of Neurology, Linyi Central Hospital, Linyi 276400, Shandong Province, China; 2Department of Neurology, Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China; 3Department of Stomatology, People’s Hospital of District Longhua Shenzhen, Shenzhen 518109, Guangdong Province, China

*These authors contributed equally to this work

Introduction: Previously published articles have suggested that BDNF rs6265 G>A polymorphism is a potential risk factor for epilepsy. However, the results were not consistent.
Methods: We conducted a meta-analysis to explore the association between BDNF rs6265 G>A polymorphism and epilepsy risk. Four online databases were searched, and related studies were reviewed from their inception up to June 20, 2017. ORs and corresponding 95% CIs were used to calculate the associations of each genetic model. Overall, 10 case–control publications involving 9,512 subjects were included in this meta-analysis.
Results: Significant associations were found between BDNF rs6265 G>A polymorphism and epilepsy (A vs G: OR=0.88, 95% CI=0.83–0.94, P<0.01, I2=0%; GA vs GG: OR=0.88, 95% CI=0.79–0.97, P=0.01, I2=0%; AA vs GG: OR=0.79, 95% CI=0.70–0.90, P<0.01, I2=0%; GA+AA vs GG: OR=0.85, 95% CI=0.77–0.94, P<0.01, I2=0%; AA vs GG+GA: OR=0.85, 95% CI=0.76–0.95, P=0.01, I2=0%). Subgroup analysis also showed similar results in an Asian population.
Conclusion: Our meta-analysis indicated that BDNF rs6265 G>A polymorphism might be involved in epilepsy susceptibility, especially in the Asian population.

Keywords: brain derived neurotrophic factor, epilepsy, seizure, polymorphism, variant, rs6265, case–control

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