Back to Journals » Journal of Inflammation Research » Volume 9

Significance of mast cell distribution in placental tissue and membranes in spontaneous preterm birth

Authors Needham K, Fadia M, Dahlstrom J, Harrington K, Shadbolt B, Robson S

Received 10 January 2015

Accepted for publication 4 May 2015

Published 8 July 2016 Volume 2016:9 Pages 141—145

DOI https://doi.org/10.2147/JIR.S80722

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Ning Quan


Kate Needham,1 Mitali Fadia,2,3 Jane E Dahlstrom,2,3 Kirsti Harrington,2,3 Bruce Shadbolt,4 Stephen J Robson,1,3,5

1Department of Obstetrics and Gynaecology, Centenary Hospital for Women and Children, Canberra Hospital, Garran, ACT, Australia; 2Department of Anatomical Pathology, ACT Pathology, Canberra Hospital, Garran, ACT, Australia; 3ANU Medical School, Australian National University, Canberra, ACT, Australia; 4Department of Epidemiology and Population Health, Canberra Hospital, Garran, ACT, Australia; 5John James Medical Centre, Deakin, ACT, Australia

Background: Preterm birth is a common cause of adverse neonatal and childhood outcomes, in both the short and long term. Preterm labor is commonly associated with inflammation at the maternal–fetal interface. There is some indirect evidence that mast cells (MCs) might represent a link between hormonal influences and local reactions leading to the onset of labor.
Patients and methods: The placentas and membranes of 51 uncomplicated spontaneous term births were compared to those from 50 spontaneous preterm births. Immunohistochemical staining for MC tryptase was undertaken allowing MC concentration, location, and degranulation status to be determined. Regression modeling was used to compare results.
Results: There were no significant differences in the demographic characteristics of the two cohorts. There were significantly more MCs in the decidua for term births than preterm births (P=0.03). The presence of histological chorioamnionitis did not affect MC concentrations.
Conclusion: Despite evidence suggesting a possible role for MCs in spontaneous preterm birth, this study found that the concentration of decidual MCs was in fact significantly lower in preterm compared to term birth.

Keywords: preterm birth, mast cells, inflammation, cohort study, regression modeling

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]