Back to Journals » OncoTargets and Therapy » Volume 9

Shorter telomere length of T-cells in peripheral blood of patients with lung cancer

Authors Qian Y, Ding T, Wei L, Cao S, Yang L

Received 16 October 2015

Accepted for publication 9 February 2016

Published 4 May 2016 Volume 2016:9 Pages 2675—2682


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Narasimha Reddy Parine

Peer reviewer comments 4

Editor who approved publication: Professor Daniele Santini

Yaqin Qian,1–3,* Tingting Ding,1–3,* Lijuan Wei,2 Shui Cao,2–4 Lili Yang1–3

1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People’s Republic of China; 2National Clinical Research Center of Cancer, Tianjin, People’s Republic of China; 3Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, People’s Republic of China; 4Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People’s Republic of China

*These authors contributed equally to this work

Purpose: Telomere shortening occurs in tumor tissues and peripheral blood lymphocytes of many common human malignancies, including lung cancer, but its variation in T-cells has never been investigated. Thus, the aim of this study was to assess telomere length in T-cells and its correlation with the clinical characteristics of patients with lung cancer.
Patients and methods: A total of 40 patients with lung cancer but without prior cancer history and 25 healthy individuals were selected. T-cells were isolated and their telomere lengths were measured using quantitative real-time polymerase chain reaction methods.
Results: Telomere length in T-cells was significantly shorter in patients with lung cancer than in controls (P<0.001). Shorter telomere length was significantly associated with increased clinical stage (P=0.008) and distant metastasis (P=0.028). Naïve T-cells from patients with lung cancer had significantly decreased telomere length when compared with those from controls (P=0.012).
Conclusion: The shortened telomere length in T-cells occurred in naïve T-cells and might be related to lung cancer progression.

Keywords: tumor, telomere’s activity, naïve T-cell, immunocompromise, telomere shortening, T lymphocytes

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]