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Shorter telomere length of T-cells in peripheral blood of patients with lung cancer

Authors Qian Y, Ding T, Wei L, Cao S, Yang L

Received 16 October 2015

Accepted for publication 9 February 2016

Published 4 May 2016 Volume 2016:9 Pages 2675—2682

DOI https://doi.org/10.2147/OTT.S98488

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Narasimha Reddy Parine

Peer reviewer comments 4

Editor who approved publication: Professor Daniele Santini


Yaqin Qian,1–3,* Tingting Ding,1–3,* Lijuan Wei,2 Shui Cao,2–4 Lili Yang1–3

1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People’s Republic of China; 2National Clinical Research Center of Cancer, Tianjin, People’s Republic of China; 3Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, People’s Republic of China; 4Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People’s Republic of China

*These authors contributed equally to this work

Purpose: Telomere shortening occurs in tumor tissues and peripheral blood lymphocytes of many common human malignancies, including lung cancer, but its variation in T-cells has never been investigated. Thus, the aim of this study was to assess telomere length in T-cells and its correlation with the clinical characteristics of patients with lung cancer.
Patients and methods: A total of 40 patients with lung cancer but without prior cancer history and 25 healthy individuals were selected. T-cells were isolated and their telomere lengths were measured using quantitative real-time polymerase chain reaction methods.
Results: Telomere length in T-cells was significantly shorter in patients with lung cancer than in controls (P<0.001). Shorter telomere length was significantly associated with increased clinical stage (P=0.008) and distant metastasis (P=0.028). Naïve T-cells from patients with lung cancer had significantly decreased telomere length when compared with those from controls (P=0.012).
Conclusion: The shortened telomere length in T-cells occurred in naïve T-cells and might be related to lung cancer progression.

Keywords: tumor, telomere’s activity, naïve T-cell, immunocompromise, telomere shortening, T lymphocytes

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