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Sex differences in the prediction of the effectiveness of paroxetine for patients with major depressive disorder identified using a receiver operating characteristic curve analysis for early response

Authors Tomita T, Norio Y, Sato Y, Nakagami T, Tsuchimine S, Kaneda A, Kaneko S

Received 7 November 2013

Accepted for publication 1 February 2014

Published 8 April 2014 Volume 2014:10 Pages 599—606

DOI https://doi.org/10.2147/NDT.S57189

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Tetsu Tomita, Yasui-Furukori Norio, Yasushi Sato, Taku Nakagami, Shoko Tsuchimine, Ayako Kaneda, Sunao Kaneko

Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan

Background: We investigated cutoff values for the early response of patients with major depressive disorder to paroxetine and their sex differences by using a receiver operating characteristic (ROC) curve analysis to predict the effectiveness of paroxetine.
Methods: In total, 120 patients with major depressive disorder were enrolled and treated with 10–40 mg/day paroxetine for 6 weeks; 89 patients completed the protocol. A clinical evaluation using the Montgomery–Asberg Depression Rating Scale (MADRS) was performed at weeks 0, 1, 2, 4, and 6.
Results: In male subjects, the cutoff values for MADRS improvement rating in week 1, week 2, and week 4 were 20.9%, 34.9%, and 33.3%, respectively. The sensitivities and the specificities were 83.3% and 80.0%, 83.3% and 80.0%, and 100% and 90%, respectively. The areas under the curve (AUC) were 0.908, 0.821, and 0.979, respectively. In female subjects, the cutoff values for the MADRS improvement rating in week 1, week 2, and week 4 were 21.4%, 35.7%, and 32.3%, respectively. The sensitivities and the specificities were 71.4% and 84.6%, 73.8% and 76.9%, and 90.5% and 76.9%, respectively. The AUCs were 0.781, 0.735, and 0.904, respectively.
Conclusion: Early improvement with paroxetine may predict the long-term response. The accuracy of the prediction for the response is higher in male subjects.

Keywords: antidepressants, paroxetine, early response, sex differences, receiver operating characteristic curve analysis

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