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Selexipag in the treatment of pulmonary arterial hypertension: design, development, and therapy

Authors Hardin EA, Chin KM

Received 30 July 2016

Accepted for publication 28 September 2016

Published 15 November 2016 Volume 2016:10 Pages 3747—3754

DOI https://doi.org/10.2147/DDDT.S103534

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Sukesh Voruganti


Elizabeth Ashley Hardin,1 Kelly M Chin2

1Department of Internal Medicine, Division of Cardiology, 2Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

Abstract: Pulmonary arterial hypertension is characterized by abnormalities in the small pulmonary arteries including increased vasoconstriction, vascular remodeling, proliferation of smooth muscle cells, and in situ thrombosis. Selexipag, a novel, oral prostacyclin receptor agonist, has been shown to improve hemodynamics in a phase II clinical trial and reduce clinical worsening in a large phase III clinical trial involving patients with pulmonary arterial hypertension. In this paper, we describe the prostacyclin signaling pathway, currently available oral prostanoid medications, and the development and clinical use of selexipag.

Keywords: selexipag, pulmonary arterial hypertension, prostacyclin

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