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Salvage treatment with apatinib for advanced non-small-cell lung cancer

Authors Song Z, Yu X, Lou G, Shi X, Zhang Y

Received 24 May 2016

Accepted for publication 26 August 2016

Published 23 March 2017 Volume 2017:10 Pages 1821—1825

DOI https://doi.org/10.2147/OTT.S113435

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Geoffrey Pietersz

Zhengbo Song,1,2 Xinmin Yu,1,2 Guangyuan Lou,1,2 Xun Shi,1,2 Yiping Zhang1,2

1Department of Chemotherapy, Zhejiang Cancer Hospital, 2Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang province, Hangzhou, People’s Republic of China

Objective: No definitive chemotherapeutic regimen has been established in patients with non-small-cell lung cancer (NSCLC) who failed second- or third-line treatment. The aim of this study was to evaluate apatinib, a VEGFR-2 inhibitor, in advanced NSCLC as salvage treatment.
Methods: We evaluated the efficacy and toxicity of apatinib in patients with previously treated advanced NSCLC from 2014 to 2015 in Zhejiang Cancer Hospital. Survival analysis was performed by the Kaplan–Meier method.
Results: Forty-two patients were included in the present study. Four patients achieved partial response, and 22 achieved stable disease, representing a response rate of 9.5% and a disease control rate of 61.9%. Median progression-free survival and overall survival were 4.2 and 6.0 months, respectively. The toxicities associated with apatinib were generally acceptable with a total grade 3/4 toxicity of 50%.
Conclusion: Apatinib appears to have some activity against advanced NSCLC when utilized as salvage treatment.

Keywords: non-small-cell lung cancer, apatinib, VEGF, efficacy

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