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ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) Syndrome—What Every Pediatrician Should Know About the Etiopathogenesis, Diagnosis and Treatment: A Review
Authors Lazea C, Sur L, Florea M
Received 22 November 2020
Accepted for publication 31 December 2020
Published 29 January 2021 Volume 2021:14 Pages 319—326
DOI https://doi.org/10.2147/IJGM.S293377
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Cecilia Lazea,1 Lucia Sur,1 Mira Florea2
1Department Pediatrics I, Emergency Pediatric Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania; 2Community Medicine Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania
Correspondence: Cecilia Lazea
Department Pediatrics I, Emergency Pediatric Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, 68, Motilor Street, Cluj-Napoca 400370, Romania
Tel +40744353764
Fax +40264402539
Email cecilialazea@umfcluj.ro
Abstract: Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, autonomic dysregulation (ROHHAD) syndrome is a rare disease with unknown and debated etiology, characterized by precipitous obesity in young children, hypoventilation and autonomic dysregulation with various endocrine abnormalities. Neuroendocrine tumors can be associated in more than half of the cases. This rare condition has a severe outcome because of high morbidity and mortality. We provide a comprehensive description of the etiopathogenetic theories of the disease, clinical presentation, diagnostic workup and treatment possibilities.
Keywords: obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulation
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