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Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid

Authors Neider D, Lindström L, Boden R

Received 25 February 2016

Accepted for publication 8 April 2016

Published 11 July 2016 Volume 2016:12 Pages 1711—1714

DOI https://doi.org/10.2147/NDT.S107178

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder


Daniel Neider, Leif H Lindström, Robert Bodén

Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden

Background: The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF), bullying, and later suicide among patients with schizophrenia.
Methods:
Ninety-nine patients with schizophrenia were included. Correlations of clinical factors, 5-HIAA and HVA, and later suicide were investigated.
Results: Twelve patients committed suicide (12%) during a 28-year follow-up period. Later suicide was correlated to bullying in childhood (P=0.02) and a lower quotient of HVA/5-HIAA in CSF (P<0.05).
Conclusion: Suicide in schizophrenia is related to childhood exposedness and CSF neurotransmitter levels.

Keywords: psychosis, risk factors, bullying, HVA, 5-HIAA, CSF

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