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Review of Research on the Role of Irisin in Tumors

Authors Zhang D, Tan X, Tang N, Huang F, Chen Z, Shi G

Received 8 January 2020

Accepted for publication 7 May 2020

Published 19 May 2020 Volume 2020:13 Pages 4423—4430

DOI https://doi.org/10.2147/OTT.S245178

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Carlos E Vigil


Deguo Zhang,1,2 Xueying Tan,2 Nan Tang,1 Fei Huang,3 Zengyin Chen,1,* Guangjun Shi2,*

1Department of Hepatobiliary Surgery, The Affiliated Qingdao Chengyang District People’s Hospital of Qingdao University, Qingdao 266109, Shandong Province, People’s Republic of China; 2Department of Hepatobiliary Surgery, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao 266000, Shandong Province, People’s Republic of China; 3Department of Gastrointestinal Hernia Surgery, Qianxinan People’s Hospital, Xingyi 562400, Guizhou Province, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Zengyin Chen
Department of Hepatobiliary Surgery, The Affiliated Qingdao Chengyang District People’s Hospital of Qingdao University, No. 600, Changcheng Road, Qingdao 266109, Shandong Province, People’s Republic of China
Tel +86 178 0623 1116
Email cyrmyygdwk@126.com
Guangjun Shi
Department of Hepatobiliary Surgery, The Affiliated Qingdao Municipal Hospital of Qingdao University, No. 1, Jiao Zhou Road, Shibei District, Qingdao 266000, Shandong Province, People’s Republic of China
Tel +86 186 6167 5603
Email zdg512198040@gmail.com

Abstract: Irisin is a newly discovered exercise-induced cytokine, produced by the proteolytic hydrolysis of fibronectin type III domain-containing protein 5 (FNDC5). Irisin is widely distributed in the human body and is involved in the browning of white adipose tissue, improving insulin resistance, improving cognitive function, and regulating bone metabolism. Recent studies have shown that irisin concentration is elevated in a variety of tumor tissues as compared with that in normal tissues. However, irisin has different effects on the proliferation and apoptosis of tumor cells in breast cancer, lung cancer, and liver cancer through various mechanisms. Irisin plays an important role in the occurrence, development, and metastasis of different tumors, suggesting that irisin can be used as a potential target for tumor diagnosis and treatment. Therefore, studying the expression and function of irisin in tumors may be of great significance for the prevention and treatment of tumors. This article reviews the research progress on the role of irisin in tumors.

Keywords: irisin, cancer, diagnosis, treatment

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