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Research progress of the clinicopathologic features of lung adenosquamous carcinoma

Authors Wang J, Wang Y, Tong M, Pan H, Li D

Received 11 July 2018

Accepted for publication 19 September 2018

Published 16 October 2018 Volume 2018:11 Pages 7011—7017

DOI https://doi.org/10.2147/OTT.S179904

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Samir Farghaly


Jing Wang,1,* Yanling Wang,1,* Mengting Tong,2 Hongming Pan,1 Da Li1

1Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang, China; 2Second Department of Oncology, The Fourth Affiliated Hospital of Xinjiang Medical University, Urumqi 830001, Xinjiang, China

*These authors contributed equally to this work

Abstract: Adenosquamous carcinoma (ASC) of the lung, a biphasic malignant tumor arising from lung tissue, is a special subtype of non-small-cell lung cancer (NSCLC) with low incidence but high tendency of invasion and poor prognosis. ASC contains components of lung adenocarcinoma (AC) and lung squamous cell carcinoma (SCC). However, there is a remarkable difference between ASC and other NSCLCs in clinical features, suggesting that ASC is not a simple mixture of AC and SCC, but is rather a more complex carcinoma with a unique molecular phenotype. At present, the research on ASC is still rare, mostly because of its complicated molecular mechanism and unclear pathological origin. The lack of cognition of ASC limits its early diagnosis and treatment, and a set of mature and effective treatment programs has not been proposed yet. In-depth study of the molecular characteristics and clinical features of ASC will not only help to better understand the scientific issues, including phenotype switching of lung cancer, the origin of tumor development, and tumor heterogeneity, but also contribute to the development of its individualized treatment. This review summarizes the recent studies concerning the clinicopathologic features and the molecular mechanisms of ASC to further facilitate the development of its individualized treatment.

Keywords: lung adenosquamous carcinoma, lung adenocarcinoma, lung squamous cell carcinoma, prognostic factor, clinicopathologic features

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