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Research Progress of Preoperative FPR, FAR or AFR in Patients with Colorectal Cancer

Authors Chen C, Liu Y, Han P, Cui B

Received 17 November 2020

Accepted for publication 3 February 2021

Published 22 February 2021 Volume 2021:13 Pages 1791—1801

DOI https://doi.org/10.2147/CMAR.S292605

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Xueqiong Zhu


Chen Chen, Yanlong Liu, Peng Han, Binbin Cui

Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, Heilongjiang Province, People’s Republic of China

Correspondence: Binbin Cui
Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, No. 150 Raod Haping, Nangang District, Harbin, 150081, Heilongjiang Province, People’s Republic of China
Tel +13351112888
Email cbbhrb@163.com

Abstract: Research has confirmed that plasma albumin (Alb), prealbumin (PA) and fibrinogen (Fib) are involved in regulating the occurrence and development of various tumors. Their levels in peripheral blood are related to the survival outcome and treatment response of patients, but the accuracy and specificity of single application have yet to be fully realized. A growing amount of evidence indicates that predictors such as preoperative fibrinogen to prealbumin ratio (FPR), fibrinogen to albumin ratio (FAR) or albumin to fibrinogen ratio (AFR) are emerging as comprehensive indicators. Indeed, their components play a key regulatory role in the progression of colorectal cancer (CRC). Preoperative FPR, FAR or AFR levels, therefore, are expected to become new biomarkers for prognosis evaluation and curative effect prediction for CRC patients and are significant in the guidance they could provide for the development of individualized treatment strategies.

Keywords: colorectal cancer, FPR, FAR or AFR, prognosis, efficacy

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