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Repository corticotropin injection in patients with rheumatoid arthritis resistant to biologic therapies

Authors Fischer PA, Rapoport RJ

Received 5 October 2017

Accepted for publication 8 January 2018

Published 7 February 2018 Volume 2018:10 Pages 13—19

DOI https://doi.org/10.2147/OARRR.S153307

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Professor Chuan-Ju Liu


Peter A Fischer,1 Ronald J Rapoport2

1Sturdy Memorial Hospital, Attleboro, MA, USA; 2Division of Rheumatology, Southcoast Health, Fall River, MA, USA

Introduction: Although synthetic and biologic disease-modifying antirheumatic drugs are available, many patients with rheumatoid arthritis have a difficult-to-control disease and need other treatment options. Repository corticotropin injection (RCI) may alleviate symptoms and exacerbations in patients with refractory disease.
Methods: Nine patients with refractory rheumatoid arthritis were included in this study. Patients were maintained on their baseline therapies with a minimum of 7.5 mg prednisone daily. RCI was given daily at 40 U for 7 days. Patients who had an adequate disease response were given 40 U twice weekly through Week 12. For patients who had inadequate disease response, the dose was increased to 80 U daily for 7 days, followed by 80 U twice weekly through Week 12.
Results: The primary endpoint was >1.2 point reduction in the Disease Activity Score 28 using C-reactive protein (DAS28-CRP) at Week 12. Secondary endpoints were improvements in Health Assessment Questionnaire-Disease Index and Functional Assessment of Chronic Illness Therapy scores. Six of the nine patients met the primary endpoint. The average change in DAS28-CRP from baseline to Week 12 was numerically greater with 40 U than with 80 U RCI. Functional Assessment of Chronic Illness Therapy and Health Assessment Questionnaire-Disease Index improved as early as Week 1, and the improvements remained throughout treatment.
Conclusion: There was no association between cortisol levels and low-dose RCI response. No serious adverse events occurred. RCI produced a clinically meaningful reduction in markers of disease activity, improved health-related quality of life, and a favorable safety profile. The response rate to RCI was substantial and shows promise in this difficult-to-treat population.

Keywords: repository corticotropin injection, rheumatoid arthritis, Disease Activity Score 28 using C-reactive protein (DAS28-CRP), health-related quality of life, biologic failure, melanocortin, refractory rheumatoid arthritis

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