Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 9 » Issue 1

Relationship between the GOLD combined COPD assessment staging system and bacterial isolation

Authors Aydemir Y, Aydemir Ö, Kalem F

Received 4 July 2014

Accepted for publication 18 July 2014

Published 27 September 2014 Volume 2014:9(1) Pages 1045—1051

DOI https://doi.org/10.2147/COPD.S70620

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Yusuf Aydemir,1 Özlem Aydemir,2 Fatma Kalem3

1Department of Respiratory Medicine, Sakarya University, Sakarya, Turkey; 2Department of Microbiology, Sakarya University, Sakarya, Turkey; 3Department of Microbiology, Konya Numune Hospital, Konya, Turkey

Background: Acute exacerbations, which are a significant cause of mortality and morbidity, adversely affect chronic obstructive pulmonary disease (COPD) prognosis by accelerating loss of lung function. It is important to know the microorganisms that commonly cause exacerbations in the patient groups classified according to clinical and functional characteristics for fast and accurate treatment of acute exacerbations.
Objectives: The last Global Initiative for Chronic Obstructive Lung Disease (GOLD) publication recommended a new staging system containing obstruction degree, frequency of exacerbations, and quality of life questionnaires. This study is designed to analyze the relationship between the bacteria isolated in acute exacerbations and new GOLD stages.
Methods: Potentially pathogenic bacteria (PPB) isolation with culture and polymerase chain reaction methods were obtained from 114 acute exacerbation COPD patients, classified into A, B, C, and D groups by analyzing the forced expiratory volume in 1 second (FEV1) value, COPD Assessment Test (CAT) score, and exacerbation frequency according to the new GOLD staging system.
Results: There was a significant correlation between exacerbation frequency and PPB isolation (P=0.002). There was no relationship between GOLD stage, FEV1, and CAT score with PPB isolation. The isolated bacteria diversity and mixed infection frequency were higher in the GOLD stage D group. Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter baumannii were isolated only from D group patients.
Conclusion: Bacterial infection may cause an acute exacerbation equally in each stage for COPD. The difference in bacterial etiology is more related to exacerbation frequency than FEV1 and CAT scores for an acute exacerbation. Determining exacerbation frequency is significant for treatment success in empirical antibiotic selection.

Keywords: chronic obstructive pulmonary disease, acute exacerbation, bacterial etiology, polymerase chain reaction, GOLD

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other article by this author:

Clinical factors and comorbidities affecting the cost of hospital-treated COPD

Deniz S, Şengül A, Aydemir Y, Çeldir Emre J, Özhan MH

International Journal of Chronic Obstructive Pulmonary Disease 2016, 11:3023-3030

Published Date: 2 December 2016

Readers of this article also read:

Understanding patient preferences and willingness to pay for hemophilia therapies

Chaugule SS, Hay JW, Young G

Patient Preference and Adherence 2015, 9:1623-1630

Published Date: 11 November 2015

Quantitative assessment of walking time and postural change in patients with COPD using a new triaxial accelerometer system

Kawagoshi A, Kiyokawa N, Sugawara K, Takahashi H, Sakata S, Miura S, Sawamura S, Satake M, Shioya T

International Journal of Chronic Obstructive Pulmonary Disease 2013, 8:397-404

Published Date: 2 September 2013

Association of cognitive judgment and shyness with frequency and quality of flow experience

Hirao K, Kobayashi R, Yabuwaki K

Psychology Research and Behavior Management 2012, 5:159-162

Published Date: 8 November 2012

Frequency of heterozygous TET2 deletions in myeloproliferative neoplasms

Joseph Tripodi, Ronald Hoffman, Vesna Najfeld, et al

Cancer Management and Research 2010, 2:219-223

Published Date: 17 September 2010