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Real-life treatment of rhinitis in Australia: a historical cohort study of prescription and over-the-counter therapies for patients with and without additional respiratory disease

Authors Price DB, Smith PK, Harvey RJ, Carney AS, Kritikos V, Bosnic-Anticevich SZ, Christian L, Skinner D, Carter V, Durieux AMS

Received 4 October 2017

Accepted for publication 14 April 2018

Published 15 August 2018 Volume 2018:9 Pages 43—54


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Christoph R. Meier

David B Price,1–3 Pete K Smith,4 Richard John Harvey,5,6 A Simon Carney,7 Vicky Kritikos,8 Sinthia Z Bosnic‑Anticevich,8,9 Louise Christian,10 Derek Skinner,3 Victoria Carter,2,3 Alice MS Durieux2

1Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK; 2Observational and Pragmatic Research Institute, Singapore, Singapore; 3Optimum Patient Care, Cambridge, UK; 4Clinical Medicine, Griffith University, Southport, QLD, Australia; 5Rhinology and Skull Base, Applied Medical Research Centre, University of New South Wales, Sydney, NSW, Australia; 6Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia; 7Department of Otolaryngology – Head and Neck Surgery, Flinders University, Adelaide, SA, Australia; 8Woolcock Institute of Medical Research, University of Sydney, NSW, Australia; 9Central Sydney Area Health Service, Sydney, NSW, Australia; 10NostraData, Kew, VIC, Australia

Background: The aim of the study was to explore rhinitis therapy purchases in different Australian regions for patients with and without additional respiratory disease, using both doctor’s prescriptions and over-the-counter (OTC) medications.
Patients and methods: It was a historical cohort study of pharmacy-related claims that included prescription or OTC rhinitis therapy, with or without asthma/COPD therapy, from January 2013 to December 2014.
Results: Overall, 4,247,193 prescription and OTC rhinitis treatments were purchased from 909 pharmacies over a calendar year; the majority were single-therapy purchases for rhinitis only patients. More multiple-therapy was purchased for rhinitis and asthma/COPD patients (4.4%) than for rhinitis only patients (4.0%), with a greater proportion purchased in VIC, SA and TAS (4.7% of rhinitis only patients and 4.5% of rhinitis and asthma/COPD patients) than in other areas. Dual therapy of oral antihistamine (OAH) and intranasal corticosteroid (INS) were the most frequently purchased multiple-therapy, with higher purchasing rates for rhinitis and asthma/COPD patients (2.6%) than for rhinitis only patients (1.6%). The most frequently purchased single therapy was OAH (70.1% of rhinitis only patients and 57.3% of rhinitis and asthma/COPD patients). First-line INS therapy was more likely to be purchased for rhinitis and asthma/COPD patients (15.3% by prescription and 11.7% OTC) than for rhinitis only patients (5.0% by prescription and 9.2% OTC); however, geographical differences in the proportion of therapies purchased OTC were noted, with a lower proportion of OTC OAH and INS purchases in Queensland and the Northern Territory for patients with and without comorbid respiratory disease.
Conclusion: Purchases of first-line INS therapy are more likely for patients with comorbid respiratory disease if they have received prescriptions and information/advice from their general practitioner. The study results indicate a need for patient information/education at the point-of-sale of OTC OAHs to enable patients to assess their nasal symptoms and receive treatment support from pharmacists. Greater availability to INSs in pharmacies as well as guidance from current guidelines and instruction in correct intranasal technique may also lead to greater uptake of INSs.

Keywords: asthma, chronic obstructive airways disease, intranasal corticosteroids, medication, oral antihistamines, over-the-counter, pharmacy

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