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Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agents

Authors Ghweil AA, Helal MM

Received 20 August 2018

Accepted for publication 7 February 2019

Published 2 April 2019 Volume 2019:12 Pages 759—762

DOI https://doi.org/10.2147/IDR.S184598

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Joachim Wink


Ali A Ghweil, Mohamad M Helal

Department of Tropical Medicine and Gastroenterology, Qena Faculty of Medicine, South Valley University, Qena, Egypt

Background: We performed a case-series analysis of reactivation of herpesvirus in patients with hepatitis C virus (HCV) infection treated with direct-acting antiviral (DAA) agents.
Methods: Eight cases were detected among 100 treated patients with DAA regimens in Qena University Hospital from June 2016 to June 2017. Herpesvirus was reactivated in eight patients who received DAA therapy. None of the cases had risk factor for herpes zoster reactivation.
Results: The DAA regimens used were sofosbuvir/daclatasvir in six cases and sofosbuvir/ledipasvir in two cases. Immune changes that follow HCV clearance might lead to reactivation of other viruses, such as herpesvirus.
Conclusion: Patients with HCV infection suspected of having herpesvirus infection should be treated promptly.

Keywords: HCV, HZ, DAA


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