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Rationale and development of image-guided intensity-modulated radiotherapy post-prostatectomy: the present standard of care?

Authors Murray J, McNair H, Dearnaley D

Received 15 May 2015

Accepted for publication 20 July 2015

Published 11 November 2015 Volume 2015:7 Pages 331—344

DOI https://doi.org/10.2147/CMAR.S51955

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Kenan Onel


Julia R Murray,1,2 Helen A McNair,2 David P Dearnaley1,2
 
1Academic Urology Unit, Institute of Cancer Research, London, 2Department of Radiotherapy, The Royal Marsden NHS Foundation Trust, Sutton, UK

Abstract: The indications for post-prostatectomy radiotherapy have evolved over the last decade, although the optimal timing, dose, and target volume remain to be well defined. The target volume is susceptible to anatomical variations with its borders interfacing with the rectum and bladder. Image-guided intensity-modulated radiotherapy has become the gold standard for radical prostate radiotherapy. Here we review the current evidence for image-guided techniques with intensity-modulated radiotherapy to the prostate bed and describe current strategies to reduce or account for interfraction and intrafraction motion.

Keywords: radiotherapy, prostate cancer, post-prostatectomy, image-guided radiation therapy

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